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    TNFAIP3 TNF alpha induced protein 3 [ Homo sapiens (human) ]

    Gene ID: 7128, updated on 12-Sep-2021

    Summary

    Official Symbol
    TNFAIP3provided by HGNC
    Official Full Name
    TNF alpha induced protein 3provided by HGNC
    Primary source
    HGNC:HGNC:11896
    See related
    Ensembl:ENSG00000118503 MIM:191163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A20; AISBL; OTUD7C; TNFA1P2
    Summary
    This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in bone marrow (RPKM 156.2), appendix (RPKM 61.9) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNFAIP3 in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (137866317..137883312)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138188396..138204449)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2539 Neighboring gene wound and keratinocyte migration associated lncRNA 2 Neighboring gene uncharacterized LOC107986649 Neighboring gene long intergenic non-protein coding RNA 2528 Neighboring gene uncharacterized LOC107986545

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
    GeneReviews: Not available
    A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
    GeneReviews: Not available
    A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
    GeneReviews: Not available
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    GeneReviews: Not available
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    GeneReviews: Not available
    Autoinflammatory syndrome, familial, Behcet-like
    MedGen: C4225218 OMIM: 616744 GeneReviews: Not available
    Compare labs
    Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
    GeneReviews: Not available
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    GeneReviews: Not available
    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
    GeneReviews: Not available
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    GeneReviews: Not available
    Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    GeneReviews: Not available
    Multiple common variants for celiac disease influencing immune gene expression.
    GeneReviews: Not available
    Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
    GeneReviews: Not available
    Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) in immature dendritic cells and monocyte-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC104522, MGC138687, MGC138688

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Lys63-specific deubiquitinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables Lys63-specific deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thiol-dependent deubiquitinase TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B-1 B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of protein localization to vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of CD40 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of bone resorption NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of chronic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoclast proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 2 signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 3 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 4 signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 5 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cellular protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K11-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K29-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K33-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of defense response to virus by host NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of germinal center formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of vascular wound healing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to muramyl dipeptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tolerance induction to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 3
    Names
    OTU domain-containing protein 7C
    putative DNA-binding protein A20
    tumor necrosis factor inducible protein A20
    tumor necrosis factor, alpha induced protein 3
    zinc finger protein A20
    NP_001257436.1
    NP_001257437.1
    NP_006281.1
    XP_005267176.1
    XP_006715618.1
    XP_011534397.1
    XP_011534398.1
    XP_024302300.1
    XP_024302301.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032761.1 RefSeqGene

      Range
      4816..20869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270507.2NP_001257436.1  tumor necrosis factor alpha-induced protein 3

      See identical proteins and their annotated locations for NP_001257436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      CB528739, DB143089, M59465
      Consensus CDS
      CCDS5187.1
      UniProtKB/Swiss-Prot
      P21580
      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    2. NM_001270508.2NP_001257437.1  tumor necrosis factor alpha-induced protein 3

      See identical proteins and their annotated locations for NP_001257437.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      CB528739, HY009939, M59465
      Consensus CDS
      CCDS5187.1
      UniProtKB/Swiss-Prot
      P21580
      Related
      ENSP00000481570.1, ENST00000612899.5
      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    3. NM_006290.4NP_006281.1  tumor necrosis factor alpha-induced protein 3

      See identical proteins and their annotated locations for NP_006281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      CB528739, HY085289, M59465
      Consensus CDS
      CCDS5187.1
      UniProtKB/Swiss-Prot
      P21580
      Related
      ENSP00000237289.4, ENST00000237289.8
      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      137866317..137883312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536095.1XP_011534397.1  tumor necrosis factor alpha-induced protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011534397.1

      UniProtKB/Swiss-Prot
      P21580
      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    2. XM_011536096.2XP_011534398.1  tumor necrosis factor alpha-induced protein 3 isoform X2

      Conserved Domains (2) summary
      smart00259
      Location:475500
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    3. XM_024446532.1XP_024302300.1  tumor necrosis factor alpha-induced protein 3 isoform X1

      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    4. XM_024446533.1XP_024302301.1  tumor necrosis factor alpha-induced protein 3 isoform X1

      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    5. XM_005267119.1XP_005267176.1  tumor necrosis factor alpha-induced protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005267176.1

      UniProtKB/Swiss-Prot
      P21580
      Related
      ENSP00000481454.1, ENST00000620204.3
      Conserved Domains (2) summary
      smart00259
      Location:759784
      ZnF_A20; A20-like zinc fingers
      pfam02338
      Location:98257
      OTU; OTU-like cysteine protease
    6. XM_006715555.1XP_006715618.1  tumor necrosis factor alpha-induced protein 3 isoform X3

      Conserved Domains (2) summary
      smart00259
      Location:546571
      ZnF_A20; A20-like zinc fingers
      cl19932
      Location:644
      OTU; OTU-like cysteine protease
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