Format

Send to:

Choose Destination
    • Showing Current items.

    TSPAN6 tetraspanin 6 [ Homo sapiens (human) ]

    Gene ID: 7105, updated on 23-Nov-2021

    Summary

    Official Symbol
    TSPAN6provided by HGNC
    Official Full Name
    tetraspanin 6provided by HGNC
    Primary source
    HGNC:HGNC:11858
    See related
    Ensembl:ENSG00000000003 MIM:300191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T245; TM4SF6; TSPAN-6
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in colon (RPKM 15.1), ovary (RPKM 15.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSPAN6 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (100627108..100637104, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (99882105..99892101, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373298 Neighboring gene tenomodulin Neighboring gene sushi repeat containing protein X-linked 2 Neighboring gene synaptotagmin like 4 Neighboring gene peptidylprolyl isomerase A pseudogene 89

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    tetraspanin-6
    Names
    A15 homolog
    putative NF-kappa-B-activating protein 321
    tetraspan TM4SF
    tetraspanin TM4-D
    transmembrane 4 superfamily member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012534.1 RefSeqGene

      Range
      4992..14690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278740.2NP_001265669.1  tetraspanin-6 isoform b precursor

      See identical proteins and their annotated locations for NP_001265669.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK309581, AL035608, DA147330, N64145
      UniProtKB/TrEMBL
      A0A024RCI0
      Conserved Domains (1) summary
      cd03161
      Location:24121
      TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    2. NM_001278741.1NP_001265670.1  tetraspanin-6 isoform b precursor

      See identical proteins and their annotated locations for NP_001265670.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AL035608, BI458635, CX868833, N64145
      UniProtKB/TrEMBL
      A0A024RCI0
      Conserved Domains (1) summary
      cd03161
      Location:24121
      TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    3. NM_001278742.1NP_001265671.1  tetraspanin-6 isoform c precursor

      See identical proteins and their annotated locations for NP_001265671.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an exon that results in an alternate 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL035608, BI458635, CN274931, N64145
      UniProtKB/TrEMBL
      A0A087WZU5
      Related
      ENSP00000482894.1, ENST00000614008.4
      Conserved Domains (1) summary
      cd03161
      Location:24121
      TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    4. NM_001278743.1NP_001265672.1  tetraspanin-6 isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AB097016, AL035608, BI458635, DA038474, N64145
      Consensus CDS
      CCDS76001.1
      UniProtKB/Swiss-Prot
      O43657
      UniProtKB/TrEMBL
      A0A087WYV6
      Related
      ENSP00000482130.1, ENST00000612152.4
      Conserved Domains (1) summary
      cl02781
      Location:24107
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    5. NM_003270.4NP_003261.1  tetraspanin-6 isoform a

      See identical proteins and their annotated locations for NP_003261.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL035608, AY358825, CX760536, N64145
      Consensus CDS
      CCDS14470.1
      UniProtKB/Swiss-Prot
      O43657
      Related
      ENSP00000362111.4, ENST00000373020.9
      Conserved Domains (1) summary
      pfam00335
      Location:17236
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      100627108..100637104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531018.1XP_011529320.1  tetraspanin-6 isoform X1

      See identical proteins and their annotated locations for XP_011529320.1

      UniProtKB/TrEMBL
      A0A024RCI0
      Conserved Domains (1) summary
      cd03161
      Location:24121
      TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    Support Center