Format

Send to:

Choose Destination
    • Showing Current items.

    TJP1 tight junction protein 1 [ Homo sapiens (human) ]

    Gene ID: 7082, updated on 15-Jun-2019

    Summary

    Official Symbol
    TJP1provided by HGNC
    Official Full Name
    tight junction protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11827
    See related
    Ensembl:ENSG00000104067 MIM:601009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZO-1
    Summary
    This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in testis (RPKM 23.9), placenta (RPKM 23.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See TJP1 in Genome Data Viewer
    Location:
    15q13.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (29699367..29968924, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (29992338..30261038, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130111 Neighboring gene uncharacterized LOC105370743 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 5 Neighboring gene non-SMC condensin I complex subunit G pseudogene 2 Neighboring gene synaptogyrin 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    NHGRI GWA Catalog
    Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The exposure to HIV-1 or HIV-1 gp120 results in a significant downregulation of tight junction proteins ZO-1, Occludin, Claudin-1, Claudin-2, Claudin-3, Claudin-4, and Claudin-5 in human retinal pigment epithelial cells PubMed
    env HIV-1 JRFL and HXB2 Env (gp120) downregulates TJP1(ZO-1) upon interaction with DC-SIGN in ARPE-19 cells and is dependent upon MMP activation PubMed
    env HIV-1 gp120-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human papillomavirus or herpes simplex virus PubMed
    env Treatment of cultured human brain endothelial cells with HIV-1 gp120 results in increased permeability of the endothelial monolayer and causes disruption and downregulation of the tight junction proteins ZO-1, ZO-2, and occludin in these cells PubMed
    env The expression of tight junction (TJ) proteins ZO-1, JAM-2, Occludin, Claudin-3 and Claudin-5 is modulated by HIV-1 gp120, and the modulated TJ expression involves Rho-A activation PubMed
    env Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC) PubMed
    Nef nef Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression PubMed
    Tat tat Downregulation of ZO-1 by treatment with HIV-1 Tat and cocaine is inhibited by VEGFR-2 or sigma receptor antagonists, suggesting that VEGFR-2 and sigma receptor are involved in the downregulation of ZO-1 by Tat and cocaine in pulmonary cells PubMed
    tat Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells PubMed
    tat HIV-1 Tat-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human herpes simplex virus PubMed
    tat The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1 PubMed
    tat Treatment of a brain endothelial cell line with HIV-1 Tat results in a decrease in total levels of ZO-1 but significantly upregulate ZO-1 protein expression in the nuclei PubMed
    tat Exposure to Tat diminishes the expression of several tight junction proteins, including occludin, zonula occludens (ZO)-1, and ZO-2 in the caveolar fraction of human brain micro vascular endothelial cells PubMed
    tat HIV-1 Tat-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human papillomavirus PubMed
    tat HIV-1 Tat B disrupts blood-brain barrier (BBB) integrity to a greater extent compared to HIV-1 Tat C. This BBB dysfunction is associated with modulated expression of tight junction proteins zona occuldens (ZO-1) and junctional adhesion molecule (JAM)-2 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cell adhesion proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cell adhesion proteins, organism-specific biosystemApoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion mole...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
      E-cadherin signaling in the nascent adherens junction
    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction trafficking and regulation, organism-specific biosystem (from REACTOME)
      Gap junction trafficking and regulation, organism-specific biosystemGap junctions are clusters of intercellular channels connecting adjacent cells and permitting the direct exchange of ions and small molecules between cells. These channels are composed of two hemicha...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Nephrin/Neph1 signaling in the kidney podocyte, organism-specific biosystem (from Pathway Interaction Database)
      Nephrin/Neph1 signaling in the kidney podocyte, organism-specific biosystem
      Nephrin/Neph1 signaling in the kidney podocyte
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Regulation of gap junction activity, organism-specific biosystem (from REACTOME)
      Regulation of gap junction activity, organism-specific biosystemSrc is believed to suppress gap junction communication by phosphorylating Cx43.
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • Vibrio cholerae infection, organism-specific biosystem (from KEGG)
      Vibrio cholerae infection, organism-specific biosystemCholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, ...
    • Vibrio cholerae infection, conserved biosystem (from KEGG)
      Vibrio cholerae infection, conserved biosystemCholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, ...
    • c-src mediated regulation of Cx43 function and closure of gap junctions, organism-specific biosystem (from REACTOME)
      c-src mediated regulation of Cx43 function and closure of gap junctions, organism-specific biosystemThe kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133289, DKFZp686M05161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding HDA PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell junction assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling involved in cell-cell junction organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment of endothelial intestinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hippo signaling TAS
    Traceable Author Statement
    more info
     
    regulation of bicellular tight junction assembly TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction TAS
    Traceable Author Statement
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    podosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tight junction protein ZO-1
    Names
    zona occludens 1
    zonula occludens 1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301025.3NP_001287954.2  tight junction protein ZO-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. The exon combination of this variant is inferred based on partial transcript alignments.
      Source sequence(s)
      AC022613, AC087455, AF035298
      Conserved Domains (8) summary
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518594
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:17281827
      ZU5; ZU5 domain
      cl27975
      Location:9471342
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
      cl28087
      Location:12281688
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    2. NM_001301026.2NP_001287955.1  tight junction protein ZO-1 isoform d

      See identical proteins and their annotated locations for NP_001287955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AB370197, AC022613, AF035298, BX640879
      Consensus CDS
      CCDS73702.1
      UniProtKB/TrEMBL
      A9CQZ8, G5E9E7, Q6MZU1
      Related
      ENSP00000382890.2, ENST00000400011.6
      Conserved Domains (7) summary
      cd12026
      Location:521585
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:619798
      GuKc; Guanylate kinase homologues
      smart00228
      Location:187267
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:26111
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:429505
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:15581656
      ZU5; ZU5 domain
      pfam07223
      Location:8691174
      DUF1421; Protein of unknown function (DUF1421)
    3. NM_001330239.3NP_001317168.1  tight junction protein ZO-1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (e) is longer than isoform a.
      Source sequence(s)
      AB370197, AC022613, AF035298, BE819398, CV571135, DA261260
      Consensus CDS
      CCDS81858.1
      UniProtKB/TrEMBL
      G3V1L9
      Related
      ENSP00000348416.6, ENST00000356107.10
      Conserved Domains (7) summary
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:425501
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:16341732
      ZU5; ZU5 domain
      pfam07223
      Location:9221250
      DUF1421; Protein of unknown function (DUF1421)
    4. NM_001355012.2NP_001341941.1  tight junction protein ZO-1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AA101028, AC022613, AC087455, AF035298, AL707462, BC111712, BE082525, BE819398, BI914113, BM459712, BQ434619, BQ575449, BX504167, BX640879, CD653673, CN372462, CN372473, CV571135, DB089107, HY197781
      Conserved Domains (8) summary
      smart00218
      Location:17251831
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd12026
      Location:610674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:115200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518594
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl27975
      Location:9471342
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
      cl28087
      Location:12281688
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    5. NM_001355013.1NP_001341942.1  tight junction protein ZO-1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC022613, AF035298, BC111712, BU618228, BX640879
      Conserved Domains (8) summary
      cd12026
      Location:521585
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:619798
      GuKc; Guanylate kinase homologues
      smart00228
      Location:187267
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:26111
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:429505
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:16391728
      ZU5; ZU5 domain
      cl27975
      Location:8581253
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
      cl28087
      Location:11391599
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    6. NM_001355014.2NP_001341943.1  tight junction protein ZO-1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC022613, AF035298, BC111712, BU618228, BX640879, L14837
      Conserved Domains (8) summary
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:425501
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:16351724
      ZU5; ZU5 domain
      cl27975
      Location:8541249
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
      cl28087
      Location:11351595
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    7. NM_001355015.2NP_001341944.1  tight junction protein ZO-1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC022613, AF035298, AK302971, BC111712, BM722482, BX640879, L14837
      Related
      ENSP00000483470.1, ENST00000614355.4
      Conserved Domains (7) summary
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:425501
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:15551654
      ZU5; ZU5 domain
      cl28087
      Location:10551515
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    8. NM_003257.5NP_003248.3  tight junction protein ZO-1 isoform a

      See identical proteins and their annotated locations for NP_003248.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as ZO-1alpha+) encodes isoform a, which is found in most epithelial cell junctions.
      Source sequence(s)
      AC022613, AF035298, BC111712, BX640879, L14837
      Consensus CDS
      CCDS42007.1
      UniProtKB/Swiss-Prot
      Q07157
      UniProtKB/TrEMBL
      Q6MZU1
      Related
      ENSP00000281537.7, ENST00000346128.10
      Conserved Domains (7) summary
      smart00218
      Location:16321738
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:425501
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam07223
      Location:9221250
      DUF1421; Protein of unknown function (DUF1421)
    9. NM_175610.4NP_783297.2  tight junction protein ZO-1 isoform b

      See identical proteins and their annotated locations for NP_783297.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as ZO-1alpha-) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Isoform b is found in both endothelial cells and the highly specialized epithelial junctions of renal glomeruli and sertoli cells of the seminiferous tubules. The exon combination of this variant is inferred based on partial transcript alignments and data in PMID:1590354.
      Source sequence(s)
      AC022613, AF035298, AK302971, BC111712, BX640879, L14837
      Consensus CDS
      CCDS45199.1
      UniProtKB/Swiss-Prot
      Q07157
      UniProtKB/TrEMBL
      B4DZK4, Q6MZU1
      Related
      ENSP00000441202.2, ENST00000545208.6
      Conserved Domains (7) summary
      smart00218
      Location:15521658
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd12026
      Location:517581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615794
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:22107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:425501
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam07223
      Location:8651170
      DUF1421; Protein of unknown function (DUF1421)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      29699367..29969049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254620.3XP_005254677.2  tight junction protein ZO-1 isoform X10

    2. XM_017022524.1XP_016878013.1  tight junction protein ZO-1 isoform X5

    3. XM_017022523.1XP_016878012.1  tight junction protein ZO-1 isoform X3

    4. XM_017022521.1XP_016878010.1  tight junction protein ZO-1 isoform X1

    5. XM_017022531.1XP_016878020.1  tight junction protein ZO-1 isoform X11

    6. XM_017022526.1XP_016878015.1  tight junction protein ZO-1 isoform X7

    7. XM_017022527.1XP_016878016.1  tight junction protein ZO-1 isoform X8

    8. XM_017022525.1XP_016878014.1  tight junction protein ZO-1 isoform X6

    9. XM_011521972.2XP_011520274.2  tight junction protein ZO-1 isoform X4

    10. XM_017022522.1XP_016878011.1  tight junction protein ZO-1 isoform X2

    11. XM_005254619.3XP_005254676.2  tight junction protein ZO-1 isoform X9

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p13 PATCHES

      Range
      1871012..2141730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p13 ALT_REF_LOCI_2

      Range
      1983496..2254214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center