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    Hars2 histidyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

    Gene ID: 70791, updated on 21-May-2019

    Summary

    Official Symbol
    Hars2provided by MGI
    Official Full Name
    histidyl-tRNA synthetase 2provided by MGI
    Primary source
    MGI:MGI:1918041
    See related
    Ensembl:ENSMUSG00000019143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HO3; HARSR; Harsl; 4631412B19Rik
    Summary
    This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of histidine to tRNA molecules. Mutations in a similar gene in human have been associated with Perrault syndrome 2 (PRLTS2). [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hars2 in Genome Data Viewer
    Location:
    18; 18 B2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (36783209..36792562)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (36942934..36952216)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase Neighboring gene zinc finger, matrin type 2 Neighboring gene vault RNA component 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histidine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histidine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    histidyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histidyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable histidine--tRNA ligase, mitochondrial
    Names
    hisRS
    histidine--tRNA ligase
    histidyl-tRNA synthetase 2, mitochondrial (putative)
    probable histidyl-tRNA synthetase, mitochondrial
    NP_001292556.1
    NP_542367.1
    XP_006526302.1
    XP_006526303.1
    XP_011245301.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305627.1NP_001292556.1  probable histidine--tRNA ligase, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_001292556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC027740, AI593507, AK077621
      Consensus CDS
      CCDS84376.1
      UniProtKB/TrEMBL
      G5E823
      Related
      ENSMUSP00000019287.8, ENSMUST00000019287.8
      Conserved Domains (3) summary
      COG0124
      Location:56422
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:69243
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:327418
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
    2. NM_001360921.1NP_001347850.1  probable histidine--tRNA ligase, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the coding region, lacks an exon in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC027740
      Conserved Domains (1) summary
      cl28413
      Location:2330
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    3. NM_080636.2NP_542367.1  probable histidine--tRNA ligase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_542367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC027740, AI593507, AK077621
      Consensus CDS
      CCDS29165.1
      UniProtKB/Swiss-Prot
      Q99KK9
      Related
      ENSMUSP00000117231.1, ENSMUST00000152954.7
      Conserved Domains (3) summary
      COG0124
      Location:56503
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:69394
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:408499
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      36783209..36792562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526239.3XP_006526302.1  probable histidine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl28413
      Location:2330
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    2. XM_006526240.3XP_006526303.1  probable histidine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd00773
      Location:69243
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    3. XM_011246999.2XP_011245301.1  probable histidine--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (2) summary
      cd00773
      Location:8254
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:268359
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RNA

    1. XR_386015.2 RNA Sequence

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