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    TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 [ Homo sapiens (human) ]

    Gene ID: 7073, updated on 9-Jun-2024

    Summary

    Official Symbol
    TIAL1provided by HGNC
    Official Full Name
    TIA1 cytotoxic granule associated RNA binding protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:11804
    See related
    Ensembl:ENSG00000151923 MIM:603413; AllianceGenome:HGNC:11804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCBP; TIAR
    Summary
    The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TIAL1 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119573465..119596964, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120471044..120494540, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121332977..121356476, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121150987-121151487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:121160908-121162107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121164620-121165120 Neighboring gene microRNA 4681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121203591-121204381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121210069-121210568 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121211884-121212060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121214023-121214544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121225296-121225796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:121239005-121239584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269325-121269826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269827-121270326 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121274963-121275176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121275942-121276524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2874 Neighboring gene regulator of G protein signaling 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4125 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121303486-121303994 Neighboring gene uncharacterized LOC105378512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121355707-121356705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121356706-121357703 Neighboring gene Sharpr-MPRA regulatory region 3145 Neighboring gene MPRA-validated peak1112 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121396416-121396639 Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33401

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR AU-rich region binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-RNA adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytolytic granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nucleolysin TIAR
    Names
    T-cluster binding protein
    TIA-1-related nucleolysin
    TIA1 related
    aging-associated gene 7 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029240.1 RefSeqGene

      Range
      5066..28565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033925.2NP_001029097.1  nucleolysin TIAR isoform 2

      See identical proteins and their annotated locations for NP_001029097.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a longer protein (isoform 2).
      Source sequence(s)
      AA972022, AC012468, AK125264, BC030025, M96954
      Consensus CDS
      CCDS31295.1
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Related
      ENSP00000358089.2, ENST00000369093.6
      Conserved Domains (3) summary
      cd12620
      Location:222294
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:10107
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:113192
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
    2. NM_001323964.2NP_001310893.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform 3.
      Source sequence(s)
      AC012468, BC030025
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82154
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:252
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001323965.2NP_001310894.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform 3.
      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82154
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:252
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001323967.2NP_001310896.1  nucleolysin TIAR isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform 3.
      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      Q49AS9
      Conserved Domains (2) summary
      cd12620
      Location:82154
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:252
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. NM_001323968.2NP_001310897.1  nucleolysin TIAR isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
    6. NM_001323969.2NP_001310898.1  nucleolysin TIAR isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC012468
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Conserved Domains (3) summary
      cd12620
      Location:166238
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:57136
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:151
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_001323970.2NP_001310899.1  nucleolysin TIAR isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC012468, BC128140
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Conserved Domains (3) summary
      cd12620
      Location:183255
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:74153
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:1968
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. NM_003252.4NP_003243.1  nucleolysin TIAR isoform 1

      See identical proteins and their annotated locations for NP_003243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AA972022, AC012468, AK125264, AL833106, BC030025
      Consensus CDS
      CCDS7613.1
      UniProtKB/Swiss-Prot
      A8K3T0, A8K4L9, Q01085
      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Related
      ENSP00000394902.2, ENST00000436547.7
      Conserved Domains (3) summary
      cd12620
      Location:205277
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12616
      Location:1090
      RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:96175
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

    RNA

    1. NR_136661.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468, AL833106
    2. NR_136662.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468
    3. NR_136663.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012468, D64015

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      119573465..119596964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448151.2XP_024303919.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
      Conserved Domains (3) summary
      cd12620
      Location:183255
      RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins
      cd12617
      Location:74153
      RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
      cl17169
      Location:1968
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_047425698.1XP_047281654.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
    3. XM_047425699.1XP_047281655.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
    4. XM_047425701.1XP_047281657.1  nucleolysin TIAR isoform X2

      UniProtKB/TrEMBL
      O15187

    RNA

    1. XR_001747194.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      120471044..120494540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366667.1XP_054222642.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
    2. XM_054366665.1XP_054222640.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
    3. XM_054366666.1XP_054222641.1  nucleolysin TIAR isoform X1

      UniProtKB/TrEMBL
      A8K5C4, Q2TSD2
    4. XM_054366669.1XP_054222644.1  nucleolysin TIAR isoform X2

      UniProtKB/TrEMBL
      O15187
    5. XM_054366668.1XP_054222643.1  nucleolysin TIAR isoform X2

      UniProtKB/TrEMBL
      O15187

    RNA

    1. XR_008488259.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022333.1: Suppressed sequence

      Description
      NM_022333.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.