U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    THBS1 thrombospondin 1 [ Homo sapiens (human) ]

    Gene ID: 7057, updated on 9-Oct-2024

    Summary

    Official Symbol
    THBS1provided by HGNC
    Official Full Name
    thrombospondin 1provided by HGNC
    Primary source
    HGNC:HGNC:11785
    See related
    Ensembl:ENSG00000137801 MIM:188060; AllianceGenome:HGNC:11785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSP; THBS; TSP1; TSP-1; THBS-1
    Summary
    The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 304.9), gall bladder (RPKM 219.5) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See THBS1 in Genome Data Viewer
    Location:
    15q14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (39581079..39599466)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37385886..37404273)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (39873280..39891667)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370784 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:39822787-39823391 Neighboring gene uncharacterized LOC124903470 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:39872371-39873108 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:39885600-39886799 Neighboring gene THBS1 intronic transcript 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:39909535-39910734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9216 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene uncharacterized LOC105370785 Neighboring gene NANOG hESC enhancer GRCh37_chr15:39958804-39959320 Neighboring gene Sharpr-MPRA regulatory region 4200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6312 Neighboring gene uncharacterized LOC105370941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9217

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env TSP1 inhibits HIV-1 infection of peripheral blood mononuclear cells and transformed T and promonocytic cell lines by its binding to HIV-1 gp120 PubMed
    env Interaction of TSP1 with HIV-1 gp120 involves CSVTCG sequences in the type 1 properdin-like repeats of TSP1 and amino acids 281-300, 311-330, and 361-380 in the C2-V3-C3 domains of gp120 PubMed
    Tat tat Thrombospondin-1 (TSP) prevents endothelial cell motility induced by HIV-1 Tat and inhibits angiogenic activity exerted by Tat in the Matrigel sponge model, suggesting downregulation of TSP may be permissive for development of KS-associated angiogenesis PubMed
    tat Thrombospondin-1 inhibits cell internalization and HIV-1 LTR transactivating activity of extracellular HIV-1 Tat, cell interaction and mitogenic activity of extracellular Tat, as well as the autocrine loop of stimulation exerted by endogenous Tat PubMed
    tat Thrombospondin-1 (TSP) binds to HIV-1 Tat, an interaction that can be inhibited by heparin which can bind to both TSP and Tat PubMed
    Vpr vpr HIV-1 Vpr potentiates the stimulation of thrombospondin 1 by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables collagen V binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables extracellular matrix structural constituent HDA PubMed 
    enables extracellular matrix structural constituent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables fibrinogen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables laminin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transforming growth factor beta binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to heat NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chronic inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in engulfment of apoptotic cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of dendritic cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of fibrinolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of focal adhesion assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of long-chain fatty acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of nitric oxide mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of plasminogen activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_negative_effect nitric oxide-cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in collagen-containing extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of fibrinogen complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thrombospondin-1
    Names
    glycoprotein G
    thrombospondin-1p180
    thrombospondin-p50

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003246.4NP_003237.2  thrombospondin-1 precursor

      See identical proteins and their annotated locations for NP_003237.2

      Status: REVIEWED

      Source sequence(s)
      AC037198, AI147670, AI168683, AK304754, BC015134, BC136470, BG115371, BM512145, BM784452, BU676185, X14787
      Consensus CDS
      CCDS32194.1
      UniProtKB/Swiss-Prot
      A8K6H4, B4E3J7, B9EGH6, P07996, Q15667, Q59E99
      Related
      ENSP00000260356.5, ENST00000260356.6
      Conserved Domains (10) summary
      smart00209
      Location:438490
      TSP1; Thrombospondin type 1 repeats
      smart00210
      Location:26221
      TSPN; Thrombospondin N-terminal -like domains
      sd00001
      Location:845882
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:787821
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:691726
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00093
      Location:318372
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:846882
      TSP_3; Thrombospondin type 3 repeat
      pfam00090
      Location:383428
      TSP_1; Thrombospondin type 1 domain
      pfam05735
      Location:9721169
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:650689
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      39581079..39599466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432980.1XP_047288936.1  thrombospondin-1 isoform X1

      UniProtKB/Swiss-Prot
      A8K6H4, B4E3J7, B9EGH6, P07996, Q15667, Q59E99
    2. XM_011521971.3XP_011520273.1  thrombospondin-1 isoform X2

      Conserved Domains (10) summary
      smart00209
      Location:438490
      TSP1; Thrombospondin type 1 repeats
      smart00210
      Location:26221
      TSPN; Thrombospondin N-terminal -like domains
      sd00001
      Location:787824
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:729763
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:633668
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:383428
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:318372
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:788824
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:9141111
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:592631
      EGF_3; EGF domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      37385886..37404273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378685.1XP_054234660.1  thrombospondin-1 isoform X1

      UniProtKB/Swiss-Prot
      A8K6H4, B4E3J7, B9EGH6, P07996, Q15667, Q59E99
    2. XM_054378686.1XP_054234661.1  thrombospondin-1 isoform X2