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    TEF TEF transcription factor, PAR bZIP family member [ Homo sapiens (human) ]

    Gene ID: 7008, updated on 25-Nov-2021

    Summary

    Official Symbol
    TEFprovided by HGNC
    Official Full Name
    TEF transcription factor, PAR bZIP family memberprovided by HGNC
    Primary source
    HGNC:HGNC:11722
    See related
    Ensembl:ENSG00000167074 MIM:188595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in brain (RPKM 21.5), ovary (RPKM 19.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See TEF in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41367455..41399326)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41763459..41795330)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Ran GTPase activating protein 1 Neighboring gene Sharpr-MPRA regulatory region 14092 Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene uncharacterized LOC100996598 Neighboring gene uncharacterized LOC105373042 Neighboring gene Sharpr-MPRA regulatory region 9842 Neighboring gene RNA, U6 small nuclear 495, pseudogene Neighboring gene HNF4 motif-containing MPRA enhancer 178 Neighboring gene uncharacterized LOC105373043 Neighboring gene transducer of ERBB2, 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1655

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    thyrotroph embryonic factor
    Names
    TEF, PAR bZIP transcription factor
    thyrotrophic embryonic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145398.3NP_001138870.1  thyrotroph embryonic factor isoform 2

      See identical proteins and their annotated locations for NP_001138870.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL008582, AL035659, BX537848, DA243618, R38583
      Consensus CDS
      CCDS46716.1
      UniProtKB/Swiss-Prot
      Q10587
      Related
      ENSP00000385256.3, ENST00000406644.7
      Conserved Domains (1) summary
      cd14695
      Location:202260
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    2. NM_003216.4NP_003207.1  thyrotroph embryonic factor isoform 1

      See identical proteins and their annotated locations for NP_003207.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL008582, AL035659, DA238847, R38583, U44059
      Consensus CDS
      CCDS14014.1
      UniProtKB/Swiss-Prot
      Q10587
      Related
      ENSP00000266304.4, ENST00000266304.9
      Conserved Domains (1) summary
      cd14695
      Location:232290
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      41367455..41399326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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