Format

Send to:

Choose Destination
    • Showing Current items.

    PRDX2 peroxiredoxin 2 [ Homo sapiens (human) ]

    Gene ID: 7001, updated on 12-Sep-2021

    Summary

    Official Symbol
    PRDX2provided by HGNC
    Official Full Name
    peroxiredoxin 2provided by HGNC
    Primary source
    HGNC:HGNC:9353
    See related
    Ensembl:ENSG00000167815 MIM:600538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
    Summary
    This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in bone marrow (RPKM 201.9), heart (RPKM 194.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRDX2 in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12796823..12801800, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12907637..12912614, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated JUNB regulatory element Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene CRISPRi-FlowFISH-validated RNASEH2A regulatory element Neighboring gene thrombospondin type 1 domain containing 8 Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element Neighboring gene ribonuclease H2 subunit A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peroxiredoxin 2 (PRDX2) at amino acid residues 47-48 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC4104

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables antioxidant activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thioredoxin peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thioredoxin peroxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to tumor cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of hydrogen peroxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in removal of superoxide radicals IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in respiratory burst involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    peroxiredoxin-2
    Names
    epididymis secretory sperm binding protein Li 2a
    natural killer cell-enhancing factor B
    thiol-specific antioxidant 1
    thioredoxin peroxidase 1
    thioredoxin-dependent peroxide reductase 1
    thioredoxin-dependent peroxiredoxin 2
    torin
    NP_005800.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029901.1 RefSeqGene

      Range
      5081..10058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005809.6NP_005800.3  peroxiredoxin-2

      See identical proteins and their annotated locations for NP_005800.3

      Status: REVIEWED

      Source sequence(s)
      BC000452, BP248561
      Consensus CDS
      CCDS12281.1
      UniProtKB/Swiss-Prot
      P32119
      UniProtKB/TrEMBL
      V9HW12
      Related
      ENSP00000301522.2, ENST00000301522.3
      Conserved Domains (1) summary
      cd03015
      Location:8179
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      12796823..12801800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181737.1: Suppressed sequence

      Description
      NM_181737.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_181738.1: Suppressed sequence

      Description
      NM_181738.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center