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    DYNLT1 dynein light chain Tctex-type 1 [ Homo sapiens (human) ]

    Gene ID: 6993, updated on 4-Dec-2022

    Summary

    Official Symbol
    DYNLT1provided by HGNC
    Official Full Name
    dynein light chain Tctex-type 1provided by HGNC
    Primary source
    HGNC:HGNC:11697
    See related
    Ensembl:ENSG00000146425 MIM:601554; AllianceGenome:HGNC:11697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CW-1; TCTEL1; TCTEX1; tctex-1
    Summary
    This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DYNLT1 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (158636474..158644743, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (159881698..159889969, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159057506..159065775, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 807 Neighboring gene transmembrane protein 181 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene microRNA 7161 Neighboring gene synaptotagmin like 3 Neighboring gene AMZ2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 4567

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr interacts with DYNLT1 (HIV-1 Vpr F72L mutant has impaired interaction with DYNLT1) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC111571

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular transport of viral protein in host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule-dependent intracellular transport of viral material towards nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of dynein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in host cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynein light chain Tctex-type 1
    Names
    T-complex testis-specific protein 1 homolog
    t-complex-associated-testis-expressed 1-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291602.2NP_001278531.1  dynein light chain Tctex-type 1 isoform 2

      See identical proteins and their annotated locations for NP_001278531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BU675683, HY017024, HY171700
      Conserved Domains (1) summary
      cd21462
      Location:899
      DLC-like_DYNLT1; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins
    2. NM_001291603.2NP_001278532.1  dynein light chain Tctex-type 1 isoform 3

      See identical proteins and their annotated locations for NP_001278532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL589931, AL591025, BU675683, DN915418, HY017024, HY171700
      Conserved Domains (1) summary
      pfam03645
      Location:1664
      Tctex-1; Tctex-1 family
    3. NM_006519.4NP_006510.1  dynein light chain Tctex-type 1 isoform 1

      See identical proteins and their annotated locations for NP_006510.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL589931, BC105588, BU675683, HY171700
      Consensus CDS
      CCDS5257.1
      UniProtKB/Swiss-Prot
      P63172, Q5VTU4
      Related
      ENSP00000356056.3, ENST00000367089.8
      Conserved Domains (1) summary
      cd21462
      Location:12113
      DLC-like_DYNLT1; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      158636474..158644743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      159881698..159889969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)