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    MIR649 microRNA 649 [ Homo sapiens (human) ]

    Gene ID: 693234, updated on 15-Jun-2019


    Official Symbol
    MIR649provided by HGNC
    Official Full Name
    microRNA 649provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000207575 miRBase:MI0003664
    Gene type
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRN649; hsa-mir-649
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

    Genomic context

    See MIR649 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (21034176..21034272, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21388465..21388561, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene THAP7 antisense RNA 1 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6 Neighboring gene solute carrier family 7 member 4 Neighboring gene purinergic receptor P2X 6 pseudogene Neighboring gene leucine rich repeat containing 74B

    Genomic regions, transcripts, and products


    Related articles in PubMed

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    RISC complex IEA
    Inferred from Electronic Annotation
    more info

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


    1. NR_030379.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      21034176..21034272 complement
      GenBank, FASTA, Sequence Viewer (Graphics)
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