U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TCEA2 transcription elongation factor A2 [ Homo sapiens (human) ]

    Gene ID: 6919, updated on 8-Dec-2022

    Summary

    Official Symbol
    TCEA2provided by HGNC
    Official Full Name
    transcription elongation factor A2provided by HGNC
    Primary source
    HGNC:HGNC:11614
    See related
    Ensembl:ENSG00000171703 MIM:604784; AllianceGenome:HGNC:11614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TFIIS
    Summary
    The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 9.5), brain (RPKM 6.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TCEA2 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64055596..64072347)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65876999..65892426)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62688325..62703700)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 204 Neighboring gene SOX18 promoter region Neighboring gene SRY-box transcription factor 18 Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription elongation factor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription elongation factor A protein 2
    Names
    testis-specific S-II
    transcription elongation factor A (SII), 2
    transcription elongation factor S-II protein 2
    transcription elongation factor TFIIS.1
    transcription elongation factor TFIIS.l

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003195.6NP_003186.1  transcription elongation factor A protein 2 isoform a

      See identical proteins and their annotated locations for NP_003186.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      BC018896, CA440059, DB482075
      Consensus CDS
      CCDS13553.1
      UniProtKB/Swiss-Prot
      Q15560, Q8TD38
      UniProtKB/TrEMBL
      Q6IB64
      Related
      ENSP00000343515.5, ENST00000343484.10
      Conserved Domains (1) summary
      cl02637
      Location:6299
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
    2. NM_198723.2NP_942016.1  transcription elongation factor A protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      BC018896, BI756937, CA440059, CB961240
      Consensus CDS
      CCDS13554.1
      UniProtKB/Swiss-Prot
      Q15560
      Related
      ENSP00000354552.2, ENST00000361317.6
      Conserved Domains (1) summary
      cl02637
      Location:1272
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      64055596..64072347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440438.1XP_047296394.1  transcription elongation factor A protein 2 isoform X2

    2. XM_024451981.2XP_024307749.1  transcription elongation factor A protein 2 isoform X2

      Conserved Domains (1) summary
      TIGR01385
      Location:1270
      TFSII; transcription elongation factor S-II
    3. XM_047440432.1XP_047296388.1  transcription elongation factor A protein 2 isoform X2

    4. XM_047440433.1XP_047296389.1  transcription elongation factor A protein 2 isoform X2

    5. XM_024451976.2XP_024307744.1  transcription elongation factor A protein 2 isoform X2

      Conserved Domains (1) summary
      TIGR01385
      Location:1270
      TFSII; transcription elongation factor S-II
    6. XM_047440436.1XP_047296392.1  transcription elongation factor A protein 2 isoform X2

    7. XM_024451984.1XP_024307752.1  transcription elongation factor A protein 2 isoform X2

      Conserved Domains (1) summary
      TIGR01385
      Location:1270
      TFSII; transcription elongation factor S-II
    8. XM_047440434.1XP_047296390.1  transcription elongation factor A protein 2 isoform X2

    9. XM_047440437.1XP_047296393.1  transcription elongation factor A protein 2 isoform X2

    10. XM_047440431.1XP_047296387.1  transcription elongation factor A protein 2 isoform X2

    11. XM_047440441.1XP_047296397.1  transcription elongation factor A protein 2 isoform X3

    12. XM_047440435.1XP_047296391.1  transcription elongation factor A protein 2 isoform X2

    13. XM_024451983.2XP_024307751.1  transcription elongation factor A protein 2 isoform X2

      Related
      ENSP00000339432.4, ENST00000339217.8
      Conserved Domains (1) summary
      TIGR01385
      Location:1270
      TFSII; transcription elongation factor S-II
    14. XM_047440439.1XP_047296395.1  transcription elongation factor A protein 2 isoform X2

      Related
      ENSP00000407085.1, ENST00000440819.5
    15. XM_024451985.2XP_024307753.1  transcription elongation factor A protein 2 isoform X2

      Conserved Domains (1) summary
      TIGR01385
      Location:1270
      TFSII; transcription elongation factor S-II
    16. XM_047440440.1XP_047296396.1  transcription elongation factor A protein 2 isoform X2

    17. XM_005260229.5XP_005260286.1  transcription elongation factor A protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005260286.1

      Conserved Domains (4) summary
      cd00183
      Location:581
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:252297
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:6297
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:136243
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
    18. XM_047440430.1XP_047296386.1  transcription elongation factor A protein 2 isoform X2

    19. XM_047440442.1XP_047296398.1  transcription elongation factor A protein 2 isoform X3

    20. XM_024451986.2XP_024307754.1  transcription elongation factor A protein 2 isoform X2

      Related
      ENSP00000416026.1, ENST00000458442.1
      Conserved Domains (1) summary
      TIGR01385
      Location:1270
      TFSII; transcription elongation factor S-II

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65876999..65892426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)