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    TAF4 TATA-box binding protein associated factor 4 [ Homo sapiens (human) ]

    Gene ID: 6874, updated on 31-Jul-2021

    Summary

    Official Symbol
    TAF4provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 4provided by HGNC
    Primary source
    HGNC:HGNC:11537
    See related
    Ensembl:ENSG00000130699 MIM:601796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAF2C; TAF4A; TAF2C1; TAFII130; TAFII135; TAFII-130; TAFII-135; TAF(II)130; TAF(II)135
    Summary
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 7.8), ovary (RPKM 4.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TAF4 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (61974798..62065881, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60549854..60640937, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cadherin 4 Neighboring gene Sharpr-MPRA regulatory region 10002 Neighboring gene uncharacterized LOC105372704 Neighboring gene microRNA 1257 Neighboring gene uncharacterized LOC105372705 Neighboring gene ribosomal protein L17 pseudogene 48 Neighboring gene uncharacterized LOC105372706 Neighboring gene microRNA 3195 Neighboring gene LSM family member 14B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
    tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ41943

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 4
    Names
    RNA polymerase II TBP-associated factor subunit C
    TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
    TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD
    TBP-associated factor 4
    transcription initiation factor TFIID 130 kDa subunit
    transcription initiation factor TFIID 135 kD subunit
    transcription initiation factor TFIID 135 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003185.4NP_003176.2  transcription initiation factor TFIID subunit 4

      See identical proteins and their annotated locations for NP_003176.2

      Status: REVIEWED

      Source sequence(s)
      AL109911, AL137077
      Consensus CDS
      CCDS33500.1
      UniProtKB/Swiss-Prot
      O00268
      Related
      ENSP00000252996.3, ENST00000252996.9
      Conserved Domains (2) summary
      pfam05236
      Location:8341082
      TAF4; Transcription initiation factor TFIID component TAF4 family
      pfam07531
      Location:592675
      TAFH; NHR1 homology to TAF

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      61974798..62065881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187623.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      85385..118232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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