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    TAF2 TATA-box binding protein associated factor 2 [ Homo sapiens (human) ]

    Gene ID: 6873, updated on 6-Jun-2024

    Summary

    Official Symbol
    TAF2provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 2provided by HGNC
    Primary source
    HGNC:HGNC:11536
    See related
    Ensembl:ENSG00000064313 MIM:604912; AllianceGenome:HGNC:11536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRT40; TAF2B; CIF150; TAFII150
    Summary
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 6.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TAF2 in Genome Data Viewer
    Location:
    8q24.12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (119730774..119832841, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (120859650..120961708, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (120743014..120845081, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 2 Neighboring gene uncharacterized LOC105375727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:120684845-120685448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:120685449-120686051 Neighboring gene RN7SK pseudogene 153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27843 Neighboring gene uncharacterized LOC105375728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19483 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene RNA, 7SL, cytoplasmic 396, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
    tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IC
    Inferred by Curator
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 2
    Names
    150 kDa cofactor of initiator function
    RNA polymerase II TBP-associated factor subunit B
    TAF(II)150
    TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD
    TBP-associated factor 150 kDa
    cofactor of initiator function, 150kD subunit
    transcription initiation factor TFIID 150 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033911.2 RefSeqGene

      Range
      5000..107067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003184.4NP_003175.2  transcription initiation factor TFIID subunit 2

      Status: REVIEWED

      Source sequence(s)
      AC021945, AC107960
      Consensus CDS
      CCDS34937.1
      UniProtKB/Swiss-Prot
      B2RE82, O43487, O43604, O60668, Q6P1X5, Q86WW7, Q8IWK4
      UniProtKB/TrEMBL
      H0YC37
      Related
      ENSP00000367406.2, ENST00000378164.7
      Conserved Domains (1) summary
      cd09839
      Location:28523
      M1_like_TAF2; TATA binding protein (TBP) associated factor 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      119730774..119832841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013779.3XP_016869268.1  transcription initiation factor TFIID subunit 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KSY6, H0YC37
      Related
      ENSP00000509978.1, ENST00000688645.1
    2. XM_011517259.3XP_011515561.1  transcription initiation factor TFIID subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5QJR0, H0YC37
      Related
      ENSP00000510174.1, ENST00000685235.1
      Conserved Domains (1) summary
      cd09839
      Location:27541
      M1_TAF2; TATA binding protein (TBP) associated factor 2
    3. XM_006716621.4XP_006716684.1  transcription initiation factor TFIID subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KV60, H0YC37
      Related
      ENSP00000509206.1, ENST00000686879.1
      Conserved Domains (1) summary
      cd09839
      Location:27541
      M1_TAF2; TATA binding protein (TBP) associated factor 2
    4. XM_017013780.2XP_016869269.1  transcription initiation factor TFIID subunit 2 isoform X4

      UniProtKB/TrEMBL
      H0YC37
      Conserved Domains (2) summary
      cd09839
      Location:2372
      M1_TAF2; TATA binding protein (TBP) associated factor 2
      pfam13646
      Location:483538
      HEAT_2; HEAT repeats
    5. XM_047422152.1XP_047278108.1  transcription initiation factor TFIID subunit 2 isoform X6

      UniProtKB/TrEMBL
      H0YC37
    6. XM_017013783.3XP_016869272.1  transcription initiation factor TFIID subunit 2 isoform X5

      UniProtKB/TrEMBL
      H0YC37
      Conserved Domains (2) summary
      pfam13646
      Location:441496
      HEAT_2; HEAT repeats
      cl14813
      Location:1330
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    7. XM_047422153.1XP_047278109.1  transcription initiation factor TFIID subunit 2 isoform X7

      Related
      ENST00000692711.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      120859650..120961708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361105.1XP_054217080.1  transcription initiation factor TFIID subunit 2 isoform X3

      UniProtKB/TrEMBL
      H0YC37
    2. XM_054361104.1XP_054217079.1  transcription initiation factor TFIID subunit 2 isoform X2

      UniProtKB/TrEMBL
      H0YC37
    3. XM_054361103.1XP_054217078.1  transcription initiation factor TFIID subunit 2 isoform X1

      UniProtKB/TrEMBL
      H0YC37
    4. XM_054361106.1XP_054217081.1  transcription initiation factor TFIID subunit 2 isoform X4

      UniProtKB/TrEMBL
      H0YC37
    5. XM_054361108.1XP_054217083.1  transcription initiation factor TFIID subunit 2 isoform X6

      UniProtKB/TrEMBL
      H0YC37
    6. XM_054361107.1XP_054217082.1  transcription initiation factor TFIID subunit 2 isoform X5

      UniProtKB/TrEMBL
      H0YC37
    7. XM_054361109.1XP_054217084.1  transcription initiation factor TFIID subunit 2 isoform X7