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    XCL2 X-C motif chemokine ligand 2 [ Homo sapiens (human) ]

    Gene ID: 6846, updated on 18-Sep-2024

    Summary

    Official Symbol
    XCL2provided by HGNC
    Official Full Name
    X-C motif chemokine ligand 2provided by HGNC
    Primary source
    HGNC:HGNC:10646
    See related
    Ensembl:ENSG00000143185 MIM:604828; AllianceGenome:HGNC:10646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCM1B; SCYC2; SCM-1b
    Summary
    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of T cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen (RPKM 4.0), bone marrow (RPKM 3.8) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See XCL2 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (168540768..168543997, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167895859..167899089, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168510006..168513235, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC125312414 Neighboring gene uncharacterized LOC101928565 Neighboring gene QRSL1 pseudogene 1 Neighboring gene MPRA-validated peak443 silencer Neighboring gene MPRA-validated peak444 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:168479196-168480395 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:168481645-168482844 Neighboring gene ribosomal protein L7a pseudogene 19 Neighboring gene ribosomal protein L7a pseudogene 21 Neighboring gene X-C motif chemokine ligand 1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:168594433-168594934 Neighboring gene uncharacterized LOC105371604

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood circulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytokine SCM-1 beta
    Names
    XC chemokine ligand 2
    c motif chemokine 2
    chemokine (C motif) ligand 2
    small inducible cytokine subfamily C, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003175.4NP_003166.1  cytokine SCM-1 beta precursor

      See identical proteins and their annotated locations for NP_003166.1

      Status: VALIDATED

      Source sequence(s)
      BC070308, BE218461
      Consensus CDS
      CCDS1273.1
      UniProtKB/Swiss-Prot
      Q9UBD3
      Related
      ENSP00000356793.2, ENST00000367819.3
      Conserved Domains (1) summary
      cd00271
      Location:2293
      Chemokine_C; Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      168540768..168543997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      167895859..167899089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)