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    SULT2A1 sulfotransferase family 2A member 1 [ Homo sapiens (human) ]

    Gene ID: 6822, updated on 15-Jun-2019

    Summary

    Official Symbol
    SULT2A1provided by HGNC
    Official Full Name
    sulfotransferase family 2A member 1provided by HGNC
    Primary source
    HGNC:HGNC:11458
    See related
    Ensembl:ENSG00000105398 MIM:125263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST
    Summary
    This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]
    Expression
    Biased expression in liver (RPKM 300.0), adrenal (RPKM 86.0) and 2 other tissues See more
    Orthologs

    Genomic context

    See SULT2A1 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (47870466..47886397, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48373723..48389654, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetrapeptide repeat homeobox 2, pseudogene Neighboring gene long intergenic non-protein coding RNA 1595 Neighboring gene Sharpr-MPRA regulatory region 10552 Neighboring gene small NF90 (ILF3) associated RNA A12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog
    Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    bile-salt sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
    Traceable Author Statement
    more info
     
    bile acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sulfation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    bile salt sulfotransferase
    Names
    alcohol/hydroxysteroid sulfotransferase
    bile-salt sulfotranasferase 2A1
    sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
    NP_003158.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016745.1 RefSeqGene

      Range
      5001..20932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003167.4NP_003158.2  bile salt sulfotransferase

      See identical proteins and their annotated locations for NP_003158.2

      Status: REVIEWED

      Source sequence(s)
      AC024582, BC020755, BX509490
      Consensus CDS
      CCDS12707.1
      UniProtKB/Swiss-Prot
      Q06520
      UniProtKB/TrEMBL
      A8K015
      Related
      ENSP00000222002.2, ENST00000222002.4
      Conserved Domains (1) summary
      pfam00685
      Location:34278
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      47870467..47886315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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