Format

Send to:

Choose Destination
    • Showing Current items.

    STXBP3 syntaxin binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 6814, updated on 8-Jul-2021

    Summary

    Official Symbol
    STXBP3provided by HGNC
    Official Full Name
    syntaxin binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:11446
    See related
    Ensembl:ENSG00000116266 MIM:608339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSP; MUNC18C; UNC-18C; MUNC18-3
    Expression
    Ubiquitous expression in thyroid (RPKM 25.5), kidney (RPKM 20.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STXBP3 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (108746674..108809523)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109289296..109352145)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 38B Neighboring gene fibronectin type III domain containing 7 Neighboring gene N-acetylneuraminic acid phosphatase pseudogene Neighboring gene uncharacterized LOC105378891 Neighboring gene AKNA domain containing 1 Neighboring gene spermatogenesis associated 42

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neutrophil degranulation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein to membrane docking IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tertiary granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    syntaxin-binding protein 3
    Names
    platelet Sec1 protein
    protein unc-18 homolog 3
    protein unc-18 homolog C
    syntaxin 4 binding protein
    unc18-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007269.4NP_009200.2  syntaxin-binding protein 3

      See identical proteins and their annotated locations for NP_009200.2

      Status: VALIDATED

      Source sequence(s)
      AF032922, CN409056
      Consensus CDS
      CCDS790.1
      UniProtKB/Swiss-Prot
      O00186
      Related
      ENSP00000359025.3, ENST00000370008.4
      Conserved Domains (1) summary
      pfam00995
      Location:33569
      Sec1; Sec1 family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      108746674..108809523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center