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    STK3 serine/threonine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 6788, updated on 5-May-2024

    Summary

    Official Symbol
    STK3provided by HGNC
    Official Full Name
    serine/threonine kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:11406
    See related
    Ensembl:ENSG00000104375 MIM:605030; AllianceGenome:HGNC:11406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KRS1; MST2
    Summary
    This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in endometrium (RPKM 3.0), placenta (RPKM 2.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    8q22.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (98343975..98942610, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (99469462..100069002, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99466861..99954838, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NIPAL2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 914, pseudogene Neighboring gene NIPA like domain containing 2 Neighboring gene uncharacterized LOC105375659 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:99271842-99273041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19396 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:99317371-99318570 Neighboring gene NANOG hESC enhancer GRCh37_chr8:99355446-99355947 Neighboring gene Sharpr-MPRA regulatory region 13929 Neighboring gene uncharacterized LOC124901988 Neighboring gene Sharpr-MPRA regulatory region 12621 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:99396932-99397599 Neighboring gene WASH complex subunit 3 pseudogene Neighboring gene VISTA enhancer hs908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99434278-99434886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19397 Neighboring gene microRNA 9903 Neighboring gene RNA, U6 small nuclear 748, pseudogene Neighboring gene potassium voltage-gated channel modifier subfamily S member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:99601941-99603140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99662307-99662918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:99662919-99663529 Neighboring gene ATP5PF pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99751213-99751712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27680 Neighboring gene Sharpr-MPRA regulatory region 12470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19398 Neighboring gene ribosomal protein L19 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99854811-99855310 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:99863496-99863646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99902922-99903422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:99924603-99925102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:99924101-99924602 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene RNA binding motif protein 4B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99956934-99957434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99957435-99957935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99959518-99960123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27681 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 7 Neighboring gene uncharacterized LOC107986872 Neighboring gene MPRA-validated peak7120 silencer Neighboring gene RN7SK pseudogene 85 Neighboring gene odd-skipped related transciption factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90748

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation involved in embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocardium development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hippo signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in primitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein localization to centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell differentiation involved in embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase 3
    Names
    KB-1458E12.1
    MST-2
    STE20-like kinase MST2
    epididymis secretory sperm binding protein
    hippo homolog
    mammalian STE20-like protein kinase 2
    serine/threonine kinase 3 (STE20 homolog, yeast)
    serine/threonine kinase 3 (Ste20, yeast homolog)
    serine/threonine-protein kinase Krs-1
    NP_001243241.1
    NP_001243242.1
    NP_006272.2
    XP_011515550.2
    XP_011515553.1
    XP_011515554.2
    XP_011515559.2
    XP_016869245.1
    XP_016869246.1
    XP_016869247.1
    XP_016869250.1
    XP_047278088.1
    XP_047278089.1
    XP_047278090.1
    XP_047278091.1
    XP_047278092.1
    XP_047278093.1
    XP_054217046.1
    XP_054217047.1
    XP_054217048.1
    XP_054217049.1
    XP_054217050.1
    XP_054217051.1
    XP_054217052.1
    XP_054217053.1
    XP_054217054.1
    XP_054217055.1
    XP_054217056.1
    XP_054217057.1
    XP_054217058.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256312.2NP_001243241.1  serine/threonine-protein kinase 3 isoform 2

      See identical proteins and their annotated locations for NP_001243241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate start codon compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AC016877, AK131363, AP003355
      Consensus CDS
      CCDS59108.1
      UniProtKB/Swiss-Prot
      Q13188
      Related
      ENSP00000429744.1, ENST00000523601.5
      Conserved Domains (3) summary
      cd06612
      Location:51306
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      smart00220
      Location:55306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam11629
      Location:465512
      Mst1_SARAH; C terminal SARAH domain of Mst1
    2. NM_001256313.2NP_001243242.1  serine/threonine-protein kinase 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AA370619, AK307787, AP002087, AP003355, AP003551
      Consensus CDS
      CCDS75774.1
      UniProtKB/TrEMBL
      A0A087WZ06
      Related
      ENSP00000482260.1, ENST00000617590.1
      Conserved Domains (2) summary
      pfam11629
      Location:326373
      Mst1_SARAH; C terminal SARAH domain of Mst1
      cl21453
      Location:23167
      PKc_like; Protein Kinases, catalytic domain
    3. NM_006281.4NP_006272.2  serine/threonine-protein kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_006272.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AP003551, BC010640, U26424
      Consensus CDS
      CCDS47900.1
      UniProtKB/Swiss-Prot
      A8K722, B3KYA7, Q13188, Q15445, Q15801, Q96FM6
      UniProtKB/TrEMBL
      A0A384MR07
      Related
      ENSP00000390500.2, ENST00000419617.7
      Conserved Domains (2) summary
      cd06612
      Location:23278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:437484
      Mst1_SARAH; C terminal SARAH domain of Mst1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      98343975..98942610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422133.1XP_047278089.1  serine/threonine-protein kinase 3 isoform X6

    2. XM_017013756.2XP_016869245.1  serine/threonine-protein kinase 3 isoform X1

    3. XM_011517251.3XP_011515553.1  serine/threonine-protein kinase 3 isoform X4

      Conserved Domains (2) summary
      cd06612
      Location:23278
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      smart00220
      Location:27278
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    4. XM_047422132.1XP_047278088.1  serine/threonine-protein kinase 3 isoform X5

    5. XM_011517252.4XP_011515554.2  serine/threonine-protein kinase 3 isoform X7

    6. XM_011517248.3XP_011515550.2  serine/threonine-protein kinase 3 isoform X2

    7. XM_047422135.1XP_047278091.1  serine/threonine-protein kinase 3 isoform X11

    8. XM_017013761.3XP_016869250.1  serine/threonine-protein kinase 3 isoform X10

    9. XM_017013758.2XP_016869247.1  serine/threonine-protein kinase 3 isoform X8

    10. XM_047422134.1XP_047278090.1  serine/threonine-protein kinase 3 isoform X9

    11. XM_017013757.2XP_016869246.1  serine/threonine-protein kinase 3 isoform X3

    12. XM_011517257.3XP_011515559.2  serine/threonine-protein kinase 3 isoform X13

    13. XM_047422137.1XP_047278093.1  serine/threonine-protein kinase 3 isoform X14

    14. XM_047422136.1XP_047278092.1  serine/threonine-protein kinase 3 isoform X12

    RNA

    1. XR_007060753.1 RNA Sequence

    2. XR_007060752.1 RNA Sequence

    3. XR_007060754.1 RNA Sequence

    4. XR_007060755.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      99469462..100069002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361076.1XP_054217051.1  serine/threonine-protein kinase 3 isoform X6

    2. XM_054361071.1XP_054217046.1  serine/threonine-protein kinase 3 isoform X1

    3. XM_054361074.1XP_054217049.1  serine/threonine-protein kinase 3 isoform X4

    4. XM_054361075.1XP_054217050.1  serine/threonine-protein kinase 3 isoform X5

    5. XM_054361077.1XP_054217052.1  serine/threonine-protein kinase 3 isoform X7

    6. XM_054361072.1XP_054217047.1  serine/threonine-protein kinase 3 isoform X2

    7. XM_054361080.1XP_054217055.1  serine/threonine-protein kinase 3 isoform X10

    8. XM_054361078.1XP_054217053.1  serine/threonine-protein kinase 3 isoform X8

    9. XM_054361079.1XP_054217054.1  serine/threonine-protein kinase 3 isoform X9

    10. XM_054361073.1XP_054217048.1  serine/threonine-protein kinase 3 isoform X3

    11. XM_054361082.1XP_054217057.1  serine/threonine-protein kinase 3 isoform X13

    12. XM_054361083.1XP_054217058.1  serine/threonine-protein kinase 3 isoform X14

    13. XM_054361081.1XP_054217056.1  serine/threonine-protein kinase 3 isoform X12

    RNA

    1. XR_008487876.1 RNA Sequence

    2. XR_008487875.1 RNA Sequence

    3. XR_008487874.1 RNA Sequence

    4. XR_008487877.1 RNA Sequence