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    TRAP1 TNF receptor associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 10131, updated on 9-Sep-2018

    Summary

    Official Symbol
    TRAP1provided by HGNC
    Official Full Name
    TNF receptor associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16264
    See related
    Ensembl:ENSG00000126602 MIM:606219; Vega:OTTHUMG00000129427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP75; HSP 75; HSP90L; TRAP-1
    Summary
    This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See TRAP1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (3658037..3717597, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3708038..3767598, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929732 Neighboring gene uncharacterized LOC105371060 Neighboring gene NLR family CARD domain containing 3 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene deoxyribonuclease 1 Neighboring gene CREB binding protein Neighboring gene uncharacterized LOC102724927

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of TNF receptor-associated protein 1 (TRAP1; HSP90L; HSP75) in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    membrane HDA PubMed 
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    heat shock protein 75 kDa, mitochondrial
    Names
    TNFR-associated protein 1
    testicular tissue protein Li 209
    tumor necrosis factor type 1 receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033088.1 RefSeqGene

      Range
      5001..64561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272049.1NP_001258978.1  heat shock protein 75 kDa, mitochondrial isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC006111, AK223205, AK299127, DB452880
      Consensus CDS
      CCDS61824.1
      UniProtKB/Swiss-Prot
      Q12931
      UniProtKB/TrEMBL
      Q53FS6
      Related
      ENSP00000442070.1, OTTHUMP00000257589, ENST00000538171.5, OTTHUMT00000438778
      Conserved Domains (3) summary
      PRK05218
      Location:34649
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:210648
      HSP90; Hsp90 protein
      pfam02518
      Location:60205
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    2. NM_016292.2NP_057376.2  heat shock protein 75 kDa, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_057376.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF154108, BC018950, DB452880
      Consensus CDS
      CCDS10508.1
      UniProtKB/Swiss-Prot
      Q12931
      UniProtKB/TrEMBL
      A0A140VJY2
      Related
      ENSP00000246957.5, OTTHUMP00000159796, ENST00000246957.9, OTTHUMT00000251586
      Conserved Domains (1) summary
      PRK05218
      Location:87702
      PRK05218; heat shock protein 90; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      3658037..3717597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522345.2XP_011520647.1  heat shock protein 75 kDa, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011520647.1

      Related
      ENSP00000458166.1, OTTHUMP00000257588, ENST00000575671.5
      Conserved Domains (3) summary
      PRK05218
      Location:2562
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:123561
      HSP90; Hsp90 protein
      pfam02518
      Location:2118
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
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