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    SSR2 signal sequence receptor subunit 2 [ Homo sapiens (human) ]

    Gene ID: 6746, updated on 15-Jun-2019

    Summary

    Official Symbol
    SSR2provided by HGNC
    Official Full Name
    signal sequence receptor subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:11324
    See related
    Ensembl:ENSG00000163479 MIM:600867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLAP; HSD25; TRAPB; TRAP-BETA
    Summary
    The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 141.0), adrenal (RPKM 105.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See SSR2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156009048..156020967, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155978839..155990758, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Rho/Rac guanine nucleotide exchange factor 2 Neighboring gene uncharacterized LOC107985209 Neighboring gene uncharacterized LOC107985210 Neighboring gene uncharacterized LOC107985208 Neighboring gene uncharacterized LOC105371729 Neighboring gene ubiquilin 4 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686F19123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    translocon-associated protein subunit beta
    Names
    SSR-beta
    signal sequence receptor subunit beta
    signal sequence receptor, beta (translocon-associated protein beta)
    translocon-associated protein beta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003145.4NP_003136.1  translocon-associated protein subunit beta precursor

      See identical proteins and their annotated locations for NP_003136.1

      Status: REVIEWED

      Source sequence(s)
      AK222600, BP196192, X74104
      Consensus CDS
      CCDS1126.1
      UniProtKB/Swiss-Prot
      P43308
      Related
      ENSP00000295702.4, ENST00000295702.9
      Conserved Domains (1) summary
      pfam05753
      Location:4179
      TRAP_beta; Translocon-associated protein beta (TRAPB)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      156009048..156020951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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