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    SRPK2 SRSF protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 6733, updated on 8-Dec-2022

    Summary

    Official Symbol
    SRPK2provided by HGNC
    Official Full Name
    SRSF protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:11306
    See related
    Ensembl:ENSG00000135250 MIM:602980; AllianceGenome:HGNC:11306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFRSK2
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nucleic acid metabolic process; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SRPK2 in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (105114740..105399357, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (106431059..106703575, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (104756821..105029838, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1004 Neighboring gene KMT2E antisense RNA 1 Neighboring gene lysine methyltransferase 2E (inactive) Neighboring gene uncharacterized LOC124901717 Neighboring gene uncharacterized LOC124901718 Neighboring gene ribosomal protein L36 pseudogene 12 Neighboring gene RWD domain containing 4 pseudogene 1 Neighboring gene RNA, U6 small nuclear 1322, pseudogene Neighboring gene small integral membrane protein 12-like Neighboring gene pseudouridine synthase 7 Neighboring gene ring finger protein 181 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ36101

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in R-loop processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IC
    Inferred by Curator
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nuclear speck organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SRSF protein kinase 2
    Names
    SFRS protein kinase 2
    SR protein kinase 2
    SR-protein-specific kinase 2
    serine kinase SRPK2
    serine/arginine-rich protein-specific kinase 2
    serine/arginine-rich splicing factor kinase 2
    serine/threonine-protein kinase SRPK2
    NP_001265202.1
    NP_001337667.1
    NP_001337668.1
    NP_001337669.1
    NP_001337670.1
    NP_001337671.1
    NP_001337672.1
    NP_001337673.1
    NP_001337674.1
    NP_001337675.1
    NP_872633.1
    NP_872634.1
    XP_006716161.1
    XP_011514838.1
    XP_011514840.1
    XP_016868050.2
    XP_024302661.1
    XP_024302662.1
    XP_024302663.1
    XP_047276728.1
    XP_047276729.1
    XP_047276730.1
    XP_047276731.1
    XP_047276732.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278273.2NP_001265202.1  SRSF protein kinase 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001265202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC004884, AC005070, BC035214, BC068547, BU632662
      Consensus CDS
      CCDS5735.1
      UniProtKB/Swiss-Prot
      P78362, Q8IYQ3
      UniProtKB/TrEMBL
      A0A024R704
      Related
      ENSP00000419791.1, ENST00000489828.5
      Conserved Domains (2) summary
      cl21453
      Location:68256
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    2. NM_001350738.2NP_001337667.1  SRSF protein kinase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC004884, AC005070, AC073138
      Consensus CDS
      CCDS5735.1
      UniProtKB/Swiss-Prot
      Q8IYQ3
      UniProtKB/TrEMBL
      A0A024R704
      Conserved Domains (2) summary
      cl21453
      Location:68256
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    3. NM_001350739.2NP_001337668.1  SRSF protein kinase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070
      Conserved Domains (3) summary
      cd14217
      Location:68256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504686
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    4. NM_001350740.2NP_001337669.1  SRSF protein kinase 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (d).
      Source sequence(s)
      AC005070, AC073138
      Conserved Domains (3) summary
      cd14217
      Location:116304
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:552734
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:389431
      Na_Ca_ex; Sodium/calcium exchanger protein
    5. NM_001350741.2NP_001337670.1  SRSF protein kinase 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC005070, AC073138
      Conserved Domains (2) summary
      cl21453
      Location:79267
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:352394
      Na_Ca_ex; Sodium/calcium exchanger protein
    6. NM_001350742.2NP_001337671.1  SRSF protein kinase 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070, AC073138
      Consensus CDS
      CCDS94172.1
      Related
      ENSP00000516319.1, ENST00000482862.2
      Conserved Domains (3) summary
      cd14217
      Location:105293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:541723
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378420
      Na_Ca_ex; Sodium/calcium exchanger protein
    7. NM_001350743.2NP_001337672.1  SRSF protein kinase 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.
      Source sequence(s)
      AC004884, AC005070, AC073138
      Consensus CDS
      CCDS94171.1
      Related
      ENSP00000417357.2, ENST00000460391.6
      Conserved Domains (3) summary
      cd14217
      Location:68256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    8. NM_001350744.2NP_001337673.1  SRSF protein kinase 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.
      Source sequence(s)
      AC004884, AC005070
      Consensus CDS
      CCDS94171.1
      Conserved Domains (3) summary
      cd14217
      Location:68256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    9. NM_001350745.2NP_001337674.1  SRSF protein kinase 2 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070
      Conserved Domains (1) summary
      cl21453
      Location:70640
      PKc_like; Protein Kinases, catalytic domain
    10. NM_001350746.2NP_001337675.1  SRSF protein kinase 2 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070, AC073138
      Conserved Domains (3) summary
      cd14217
      Location:105293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:545610
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378420
      Na_Ca_ex; Sodium/calcium exchanger protein
    11. NM_182691.3NP_872633.1  SRSF protein kinase 2 isoform b precursor

      See identical proteins and their annotated locations for NP_872633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      BC035214, BU632662, CR746049, DA592321
      Consensus CDS
      CCDS5735.1
      UniProtKB/Swiss-Prot
      P78362, Q8IYQ3
      UniProtKB/TrEMBL
      A0A024R704
      Related
      ENSP00000349863.3, ENST00000357311.7
      Conserved Domains (2) summary
      cl21453
      Location:68256
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    12. NM_182692.3NP_872634.1  SRSF protein kinase 2 isoform a

      See identical proteins and their annotated locations for NP_872634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      BC035214, BU632662, CR746049, HY031357
      Consensus CDS
      CCDS34724.1
      UniProtKB/Swiss-Prot
      P78362
      Related
      ENSP00000377262.3, ENST00000393651.8
      Conserved Domains (2) summary
      smart00220
      Location:92236
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:79267
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      105114740..105399357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516536.4XP_011514838.1  SRSF protein kinase 2 isoform X5

      Conserved Domains (2) summary
      cd14217
      Location:79267
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:515728
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011516538.3XP_011514840.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_011514840.1

      Conserved Domains (3) summary
      cd14217
      Location:68256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    3. XM_024446895.2XP_024302663.1  SRSF protein kinase 2 isoform X4

      Conserved Domains (3) summary
      cd14217
      Location:116304
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:552734
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:389431
      Na_Ca_ex; Sodium/calcium exchanger protein
    4. XM_024446894.2XP_024302662.1  SRSF protein kinase 2 isoform X3

      Conserved Domains (3) summary
      cd14217
      Location:116304
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:552765
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:389431
      Na_Ca_ex; Sodium/calcium exchanger protein
    5. XM_017012561.3XP_016868050.2  SRSF protein kinase 2 isoform X2

      Conserved Domains (3) summary
      cd14217
      Location:105293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:541723
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378420
      Na_Ca_ex; Sodium/calcium exchanger protein
    6. XM_024446893.2XP_024302661.1  SRSF protein kinase 2 isoform X1

      Conserved Domains (3) summary
      cd14217
      Location:105293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:541754
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378420
      Na_Ca_ex; Sodium/calcium exchanger protein
    7. XM_047420772.1XP_047276728.1  SRSF protein kinase 2 isoform X6

    8. XM_047420776.1XP_047276732.1  SRSF protein kinase 2 isoform X9

    9. XM_047420773.1XP_047276729.1  SRSF protein kinase 2 isoform X7

    10. XM_047420774.1XP_047276730.1  SRSF protein kinase 2 isoform X8

      Related
      ENSP00000420208.2, ENST00000477925.6
    11. XM_006716098.4XP_006716161.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_006716161.1

      Conserved Domains (3) summary
      cd14217
      Location:68256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341383
      Na_Ca_ex; Sodium/calcium exchanger protein
    12. XM_047420775.1XP_047276731.1  SRSF protein kinase 2 isoform X8

    RNA

    1. XR_007060151.1 RNA Sequence

    2. XR_007060150.1 RNA Sequence

    3. XR_007060147.1 RNA Sequence

    4. XR_001744862.3 RNA Sequence

    5. XR_007060153.1 RNA Sequence

    6. XR_007060148.1 RNA Sequence

    7. XR_007060149.1 RNA Sequence

    8. XR_001744863.3 RNA Sequence

    9. XR_001744861.3 RNA Sequence

    10. XR_007060152.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      106431059..106703575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)