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    SPOCK1 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 [ Homo sapiens (human) ]

    Gene ID: 6695, updated on 15-Jun-2019

    Summary

    Official Symbol
    SPOCK1provided by HGNC
    Official Full Name
    SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1provided by HGNC
    Primary source
    HGNC:HGNC:11251
    See related
    Ensembl:ENSG00000152377 MIM:602264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIC1; SPOCK; TESTICAN
    Summary
    This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 74.1), prostate (RPKM 36.6) and 10 other tissues See more
    Orthologs

    Genomic context

    See SPOCK1 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (136975298..137499329, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (136310987..136835018, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 49 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 193 Neighboring gene uncharacterized LOC105379192 Neighboring gene VISTA enhancer hs2181 Neighboring gene kelch like family member 3 Neighboring gene microRNA 874

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ37170

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metalloendopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    central nervous system neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    node of Ranvier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic density NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sarcoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    testican-1
    Names
    SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034127.1 RefSeqGene

      Range
      5001..529032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004598.4NP_004589.1  testican-1 precursor

      See identical proteins and their annotated locations for NP_004589.1

      Status: REVIEWED

      Source sequence(s)
      AC005213, AF231124, BC030691, BI550122
      Consensus CDS
      CCDS4191.1
      UniProtKB/Swiss-Prot
      Q08629
      Related
      ENSP00000378401.1, ENST00000394945.6
      Conserved Domains (4) summary
      cd00191
      Location:312372
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:197315
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam07648
      Location:139178
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam10591
      Location:196302
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      136975298..137499326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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