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    SNRNP70 small nuclear ribonucleoprotein U1 subunit 70 [ Homo sapiens (human) ]

    Gene ID: 6625, updated on 15-Jun-2019

    Summary

    Official Symbol
    SNRNP70provided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein U1 subunit 70provided by HGNC
    Primary source
    HGNC:HGNC:11150
    See related
    Ensembl:ENSG00000104852 MIM:180740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K
    Expression
    Ubiquitous expression in prostate (RPKM 63.5), spleen (RPKM 63.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See SNRNP70 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49085140..49108613)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49588465..49611870)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene RNA, 7SL, cytoplasmic 708, pseudogene Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene chromosome 19 open reading frame 73 Neighboring gene PTPRF interacting protein alpha 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein 70kDa (SNRNP70), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRNP70 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U1-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U1-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, U1-snRNP, conserved biosystem (from KEGG)
      Spliceosome, U1-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    U1 snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    negative regulation of chaperone-mediated autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein refolding TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ATPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U1 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U1 small nuclear ribonucleoprotein 70 kDa
    Names
    U1 snRNP 70 kDa
    small nuclear ribonucleoprotein 70kDa (U1)
    small nuclear ribonucleoprotein, U1 70kDa subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301069.2NP_001287998.1  U1 small nuclear ribonucleoprotein 70 kDa isoform 2

      See identical proteins and their annotated locations for NP_001287998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AL560281, BC001315, DB189176, X06815
      Consensus CDS
      CCDS74417.1
      UniProtKB/Swiss-Prot
      P08621
      Related
      ENSP00000221448.5, ENST00000221448.9
      Conserved Domains (2) summary
      cd12236
      Location:102187
      RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
      pfam12220
      Location:393
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
    2. NM_003089.6NP_003080.2  U1 small nuclear ribonucleoprotein 70 kDa isoform 1

      See identical proteins and their annotated locations for NP_003080.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC001315, BM969999, DB189176, X06815
      Consensus CDS
      CCDS12756.1
      UniProtKB/Swiss-Prot
      P08621
      UniProtKB/TrEMBL
      A0A024QZD5
      Related
      ENSP00000472998.1, ENST00000598441.6
      Conserved Domains (2) summary
      cd12236
      Location:102187
      RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
      pfam12220
      Location:393
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      49085451..49108606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527240.2XP_011525542.2  U1 small nuclear ribonucleoprotein 70 kDa isoform X1

    2. XM_011527241.2XP_011525543.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X2

      See identical proteins and their annotated locations for XP_011525543.1

      UniProtKB/TrEMBL
      Q9UFS1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009820.1: Suppressed sequence

      Description
      NM_001009820.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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