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    SUMO2 small ubiquitin like modifier 2 [ Homo sapiens (human) ]

    Gene ID: 6613, updated on 4-Dec-2022

    Summary

    Official Symbol
    SUMO2provided by HGNC
    Official Full Name
    small ubiquitin like modifier 2provided by HGNC
    Primary source
    HGNC:HGNC:11125
    See related
    Ensembl:ENSG00000188612 MIM:603042; AllianceGenome:HGNC:11125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2
    Summary
    This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 121.8), lymph node (RPKM 108.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SUMO2 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75165586..75182959, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76057065..76074452, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73161681..73179054, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 7 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of SMT3 suppressor of mif two 3 homolog 2 (SUMO2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol SUMOylation of HIV-1 IN at positions K46, K136, and K244 by SUMO involves HIV-1 infectivity PubMed
    gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117191

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small ubiquitin-related modifier 2
    Names
    SMT3 homolog 2
    SMT3 suppressor of mif two 3 homolog 2
    sentrin 2
    ubiquitin-like protein SMT3A
    ubiquitin-like protein SMT3B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005849.2NP_001005849.1  small ubiquitin-related modifier 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001005849.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (b), compared to isoform a. The amino acid sequence of isoform b is predicted and has not been experimentally verified.
      Source sequence(s)
      AC022211, BC008450, BF700114
      Consensus CDS
      CCDS45773.1
      UniProtKB/Swiss-Prot
      P61956
      Related
      ENSP00000400886.2, ENST00000314523.7
      Conserved Domains (1) summary
      cl28922
      Location:1764
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. NM_006937.4NP_008868.3  small ubiquitin-related modifier 2 isoform a precursor

      See identical proteins and their annotated locations for NP_008868.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC022211, AK024823, BC008450
      Consensus CDS
      CCDS45774.1
      UniProtKB/Swiss-Prot
      P61956, Q96HK1
      UniProtKB/TrEMBL
      A0A024R8S3
      Related
      ENSP00000405965.2, ENST00000420826.7
      Conserved Domains (1) summary
      cd16115
      Location:1788
      Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75165586..75182959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76057065..76074452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)