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    POLR3D RNA polymerase III subunit D [ Homo sapiens (human) ]

    Gene ID: 661, updated on 15-Jun-2019

    Summary

    Official Symbol
    POLR3Dprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Dprovided by HGNC
    Primary source
    HGNC:HGNC:1080
    See related
    Ensembl:ENSG00000168495 MIM:187280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPC4; BN51T; RPC53; TSBN51
    Summary
    This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 12.6), placenta (RPKM 8.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See POLR3D in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (22245104..22251167)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22102619..22108680)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein Neighboring gene microRNA 320a Neighboring gene uncharacterized LOC100507071 Neighboring gene piwi like RNA-mediated gene silencing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC4
    Names
    BN51 (BHK21) temperature sensitivity complementing
    DNA-directed RNA polymerase III 47 kDa polypeptide
    DNA-directed RNA polymerase III subunit D
    RNA polymerase III 47 kDa subunit
    RNA polymerase III subunit C4
    RPC53 homolog
    polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
    polymerase (RNA) III subunit D
    temperature sensitive complementation, cell cycle specific, tsBN51
    NP_001713.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001722.3NP_001713.2  DNA-directed RNA polymerase III subunit RPC4

      See identical proteins and their annotated locations for NP_001713.2

      Status: REVIEWED

      Source sequence(s)
      AC105206, AK026588, AY092086, BQ006609
      Consensus CDS
      CCDS34858.1
      UniProtKB/Swiss-Prot
      P05423
      Related
      ENSP00000303088.4, ENST00000306433.9
      Conserved Domains (1) summary
      pfam05132
      Location:321387
      RNA_pol_Rpc4; RNA polymerase III RPC4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      22245104..22254601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_949463.2 RNA Sequence

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