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    NME1-NME2 NME1-NME2 readthrough [ Homo sapiens (human) ]

    Gene ID: 654364, updated on 9-Jun-2019

    Summary

    Official Symbol
    NME1-NME2provided by HGNC
    Official Full Name
    NME1-NME2 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:33531
    See related
    Ensembl:ENSG00000011052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NMELV; NM23-LV
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in colon (RPKM 115.4), ovary (RPKM 91.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See NME1-NME2 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (51153536..51171744)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49230897..49249105)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371825 Neighboring gene sperm associated antigen 9 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene mbt domain containing 1 Neighboring gene UTP18 small subunit processome component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough NME1-NME2

    Included genes: NME1, NME2

    Homology

    Clone Names

    • FLJ93990

    General protein information

    Preferred Names
    NME1-NME2 protein
    Names
    NME1-NME2 readthrough transcript
    NP_001018146.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018136.3NP_001018146.1  NME1-NME2 protein

      See identical proteins and their annotated locations for NP_001018146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
      Source sequence(s)
      AC005839, BC133029, DQ109675
      Consensus CDS
      CCDS32682.1
      UniProtKB/Swiss-Prot
      P22392
      Related
      ENSP00000376889.2, ENST00000393193.6
      Conserved Domains (4) summary
      PTZ00093
      Location:118266
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
      smart00562
      Location:5114
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04413
      Location:5114
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
      pfam00334
      Location:120254
      NDK; Nucleoside diphosphate kinase

    RNA

    1. NR_037149.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF may render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005839, BC107894, DQ109675
      Related
      ENST00000555572.1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      51153536..51171744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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