U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ACTR3C actin related protein 3C [ Homo sapiens (human) ]

    Gene ID: 653857, updated on 17-Sep-2024

    Summary

    Official Symbol
    ACTR3Cprovided by HGNC
    Official Full Name
    actin related protein 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:37282
    See related
    Ensembl:ENSG00000106526 AllianceGenome:HGNC:37282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARP11
    Summary
    Predicted to enable ATP binding activity. Predicted to contribute to actin filament binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 1.0), adrenal (RPKM 0.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACTR3C in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149881360..150323545, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151063321..151501798, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149578449..150020634, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552405-149552958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552959-149553510 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149570857-149571825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18770 Neighboring gene zinc finger protein 862 Neighboring gene ATPase H+ transporting V0 subunit e2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:149604113-149604612 Neighboring gene uncharacterized LOC124901772 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:149697909-149698096 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149721691-149722215 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149728774-149729275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149732655-149733170 Neighboring gene uncharacterized LOC100134040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149745856-149746490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149746491-149747124 Neighboring gene Sharpr-MPRA regulatory region 3139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917438-149917972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149917973-149918507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149966003-149966503 Neighboring gene NANOG hESC enhancer GRCh37_chr7:149976749-149977333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149983589-149984090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149984091-149984590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26822 Neighboring gene Sharpr-MPRA regulatory region 1750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18774 Neighboring gene leucine rich repeat containing 61 Neighboring gene zinc finger BED-type containing 10, pseudogene Neighboring gene retinoic acid receptor responder 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    actin-related protein 3C
    Names
    ARP3 actin related protein 3 homolog C
    actin-related Arp11
    actin-related protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164458.2NP_001157930.1  actin-related protein 3C isoform a precursor

      See identical proteins and their annotated locations for NP_001157930.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 2, encodes the longest isoform (a).
      Source sequence(s)
      AB039791, BM674900, DA868104, DN992136, DR004860
      Consensus CDS
      CCDS47744.1
      UniProtKB/Swiss-Prot
      Q5CZI4, Q9C0K3
      UniProtKB/TrEMBL
      A0A0A0MTI9
      Related
      ENSP00000507618.1, ENST00000683684.1
      Conserved Domains (1) summary
      cl25542
      Location:1188
      Actin; Actin
    2. NM_001164459.2NP_001157931.1  actin-related protein 3C isoform a precursor

      See identical proteins and their annotated locations for NP_001157931.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
      Source sequence(s)
      AB039791, AC005586, BM674900
      Consensus CDS
      CCDS47744.1
      UniProtKB/Swiss-Prot
      Q5CZI4, Q9C0K3
      UniProtKB/TrEMBL
      A0A0A0MTI9
      Related
      ENSP00000252071.4, ENST00000252071.8
      Conserved Domains (1) summary
      cl25542
      Location:1188
      Actin; Actin
    3. NM_001351027.2NP_001337956.1  actin-related protein 3C isoform b

      Status: VALIDATED

      Source sequence(s)
      AC092666, AC092681, AC093458
      Conserved Domains (1) summary
      PTZ00280
      Location:19117
      PTZ00280; Actin-related protein 3; Provisional
    4. NM_001351028.2NP_001337957.1  actin-related protein 3C isoform c

      Status: VALIDATED

      Source sequence(s)
      AC005586, AC092681, AC093458
      Conserved Domains (1) summary
      cl25542
      Location:9107
      Actin
    5. NM_001351029.2NP_001337958.1  actin-related protein 3C isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform d.
      Source sequence(s)
      AC006008, AC092681, AC093458
      Conserved Domains (1) summary
      cl25542
      Location:2059
      Actin
    6. NM_001351030.2NP_001337959.1  actin-related protein 3C isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform d.
      Source sequence(s)
      AC006008, AC092681, AC093458
      Conserved Domains (1) summary
      cl25542
      Location:2059
      Actin

    RNA

    1. NR_147012.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005586, AC006008, AC092681, AC093458
    2. NR_147013.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005586, AC006008
      Related
      ENST00000478393.5
    3. NR_147014.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006008, AC092681, AC093458
    4. NR_147015.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006008, AC092681, AC093458
    5. NR_147016.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006008, AC092681, AC093458
    6. NR_147017.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006008, AC092681, AC093458
    7. NR_147018.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006008, AC092681, AC093458
    8. NR_147019.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006008, AC092681, AC093458
    9. NR_147020.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092666, AC092681, AC093458
    10. NR_147021.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092666, AC092681, AC093458
    11. NR_147022.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092666, AC092681, AC093458

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149881360..150323545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420750.1XP_047276706.1  actin-related protein 3C isoform X6

      Conserved Domains (1) summary
      PTZ00280
      Location:19117
      PTZ00280; Actin-related protein 3; Provisional
    2. XM_024446884.2XP_024302652.1  actin-related protein 3C isoform X6

      Conserved Domains (1) summary
      PTZ00280
      Location:19117
      PTZ00280; Actin-related protein 3; Provisional
    3. XM_047420751.1XP_047276707.1  actin-related protein 3C isoform X6

      Conserved Domains (1) summary
      PTZ00280
      Location:19117
      PTZ00280; Actin-related protein 3; Provisional
    4. XM_047420749.1XP_047276705.1  actin-related protein 3C isoform X4

      UniProtKB/TrEMBL
      A0A0A0MTI9
      Related
      ENSP00000440990.2, ENST00000539352.5
    5. XM_047420748.1XP_047276704.1  actin-related protein 3C isoform X1

    6. XM_011516508.3XP_011514810.1  actin-related protein 3C isoform X2

      See identical proteins and their annotated locations for XP_011514810.1

      UniProtKB/Swiss-Prot
      Q5CZI4, Q9C0K3
      UniProtKB/TrEMBL
      A0A0A0MTI9
      Conserved Domains (1) summary
      cl25542
      Location:1188
      Actin; Actin
    7. XM_011516507.3XP_011514809.1  actin-related protein 3C isoform X2

      See identical proteins and their annotated locations for XP_011514809.1

      UniProtKB/Swiss-Prot
      Q5CZI4, Q9C0K3
      UniProtKB/TrEMBL
      A0A0A0MTI9
      Conserved Domains (1) summary
      cl25542
      Location:1188
      Actin; Actin
    8. XM_011516506.4XP_011514808.1  actin-related protein 3C isoform X2

      See identical proteins and their annotated locations for XP_011514808.1

      UniProtKB/Swiss-Prot
      Q5CZI4, Q9C0K3
      UniProtKB/TrEMBL
      A0A0A0MTI9
      Conserved Domains (1) summary
      cl25542
      Location:1188
      Actin; Actin
    9. XM_005250043.5XP_005250100.3  actin-related protein 3C isoform X3

      UniProtKB/TrEMBL
      A0A0A0MTI9
      Conserved Domains (1) summary
      cl17037
      Location:1188
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    10. XM_011516511.4XP_011514813.1  actin-related protein 3C isoform X5

      UniProtKB/TrEMBL
      A0A0A0MTI9
      Conserved Domains (1) summary
      cl17037
      Location:1190
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. XR_007060145.1 RNA Sequence

    2. XR_007060143.1 RNA Sequence

    3. XR_007060144.1 RNA Sequence

    4. XR_007060142.1 RNA Sequence

    5. XR_007060141.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151063321..151501798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)