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    Asb2 ankyrin repeat and SOCS box-containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 65256, updated on 31-Jan-2019

    Summary

    Official Symbol
    Asb2provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 2provided by MGI
    Primary source
    MGI:MGI:1929743
    See related
    Ensembl:ENSMUSG00000021200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110008E15Rik
    Expression
    Biased expression in heart adult (RPKM 165.8), spleen adult (RPKM 62.0) and 11 other tissues See more
    Orthologs

    Genomic context

    See Asb2 in Genome Data Viewer
    Location:
    12 E; 12 52.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (103321142..103356001, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (104559352..104594211, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene proline rich membrane anchor 1 Neighboring gene family with sequence similarity 181, member A Neighboring gene predicted gene 29508 Neighboring gene predicted gene 15523 Neighboring gene OTU domain, ubiquitin aldehyde binding 2 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 2
    Names
    ASB-2
    ankyrin repeat and SOCS box-containing protein 2
    ankyrin repeat-containing SOCS box protein 2
    asb2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023049.1NP_075536.1  ankyrin repeat and SOCS box protein 2

      See identical proteins and their annotated locations for NP_075536.1

      Status: PROVISIONAL

      Source sequence(s)
      BC031161
      Consensus CDS
      CCDS26128.1
      UniProtKB/Swiss-Prot
      Q8K0L0
      Related
      ENSMUSP00000021617.7, ENSMUST00000021617.13
      Conserved Domains (5) summary
      cd00204
      Location:232357
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:308397
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:106157
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
      cl02533
      Location:590634
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      103321142..103356001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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