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    RTN4R reticulon 4 receptor [ Homo sapiens (human) ]

    Gene ID: 65078, updated on 15-Jun-2019

    Summary

    Official Symbol
    RTN4Rprovided by HGNC
    Official Full Name
    reticulon 4 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:18601
    See related
    Ensembl:ENSG00000040608 MIM:605566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NGR; NOGOR
    Summary
    This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues See more
    Orthologs

    Genomic context

    See RTN4R in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (20241415..20268293, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20228938..20255816, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372862 Neighboring gene long intergenic non-protein coding RNA 896 Neighboring gene uncharacterized LOC105372863 Neighboring gene uncharacterized LOC105372864 Neighboring gene microRNA 1286 Neighboring gene proline dehydrogenase 1 pseudogene Neighboring gene DiGeorge syndrome critical region gene 6 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Schizophrenia
    MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ganglioside GM1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ganglioside GT1b binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuregulin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of axonogenesis TAS
    Traceable Author Statement
    more info
     
    negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    reticulon-4 receptor
    Names
    Nogo-66 receptor
    UNQ330/PRO526
    nogo receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012176.2 RefSeqGene

      Range
      5001..31879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_023004.6NP_075380.1  reticulon-4 receptor precursor

      See identical proteins and their annotated locations for NP_075380.1

      Status: REVIEWED

      Source sequence(s)
      AC007663, AL834449, BM762412
      Consensus CDS
      CCDS13777.1
      UniProtKB/Swiss-Prot
      Q9BZR6
      Related
      ENSP00000043402.7, ENST00000043402.8
      Conserved Domains (4) summary
      sd00033
      Location:6082
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:156214
      LRR_8; Leucine rich repeat
      cl25642
      Location:332417
      DUF390; Protein of unknown function (DUF390)
      cl26793
      Location:82260
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      20241415..20268318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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