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    CENPH centromere protein H [ Homo sapiens (human) ]

    Gene ID: 64946, updated on 9-Jun-2024

    Summary

    Official Symbol
    CENPHprovided by HGNC
    Official Full Name
    centromere protein Hprovided by HGNC
    Primary source
    HGNC:HGNC:17268
    See related
    Ensembl:ENSG00000153044 MIM:605607; AllianceGenome:HGNC:17268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 14.9), bone marrow (RPKM 9.5) and 20 other tissues See more
    Orthologs
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    Genomic context

    See CENPH in Genome Data Viewer
    Location:
    5q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (69189583..69210357)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (70012189..70032958)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68485410..68506184)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC112267932 Neighboring gene cyclin B1 Neighboring gene Sharpr-MPRA regulatory region 51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22641 Neighboring gene Sharpr-MPRA regulatory region 69 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68515812-68516436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68530435-68530963 Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:68532675-68533175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68545886-68546386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68546387-68546887 Neighboring gene cyclin dependent kinase 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68561629-68562129 Neighboring gene coiled-coil domain containing 125

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr and p300/HAT co-localizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinetochore binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinetochore binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kinetochore organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of inner kinetochore IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    centromere protein H
    Names
    CENP-H
    interphase centromere complex protein 35
    kinetochore protein CENP-H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022909.4NP_075060.1  centromere protein H

      See identical proteins and their annotated locations for NP_075060.1

      Status: REVIEWED

      Source sequence(s)
      AC022107
      Consensus CDS
      CCDS3998.1
      UniProtKB/Swiss-Prot
      A8K3Y1, Q9H3R5
      UniProtKB/TrEMBL
      A0A0S2Z5T0, B3KVZ3
      Related
      ENSP00000283006.2, ENST00000283006.7
      Conserved Domains (2) summary
      pfam05837
      Location:126239
      CENP-H; Centromere protein H (CENP-H)
      cl25731
      Location:42208
      PRK10246; exonuclease subunit SbcC; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      69189583..69210357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      70012189..70032958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)