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    TBC1D15 TBC1 domain family member 15 [ Homo sapiens (human) ]

    Gene ID: 64786, updated on 18-Sep-2024

    Summary

    Official Symbol
    TBC1D15provided by HGNC
    Official Full Name
    TBC1 domain family member 15provided by HGNC
    Primary source
    HGNC:HGNC:25694
    See related
    Ensembl:ENSG00000121749 MIM:612662; AllianceGenome:HGNC:25694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB7-GAP
    Summary
    This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.9), adrenal (RPKM 9.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TBC1D15 in Genome Data Viewer
    Location:
    12q21.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (71839759..71924313)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (71817237..71901791)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (72233539..72318093)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:72103459-72104658 Neighboring gene uncharacterized LOC107984530 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:72119048-72120247 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72141645-72141854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6664 Neighboring gene RAB21, member RAS oncogene family Neighboring gene MPRA-validated peak1826 silencer Neighboring gene Sharpr-MPRA regulatory region 15327 Neighboring gene MRS2 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72332491-72332790 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:72342997-72343855 Neighboring gene NANOG hESC enhancer GRCh37_chr12:72352432-72352933 Neighboring gene Sharpr-MPRA regulatory region 15256 Neighboring gene NANOG hESC enhancer GRCh37_chr12:72431129-72431630 Neighboring gene tryptophan hydroxylase 2 Neighboring gene thyrotropin releasing hormone degrading enzyme Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:72608405-72609204 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:72609205-72610002 Neighboring gene TRHDE antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with TBC1 domain family, member 15 (TBC1D15) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12085, FLJ33191, DKFZp686M1379, DKFZp761D0223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 15
    Names
    GAP for RAB7
    GTPase-activating protein RAB7
    Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15
    Tre2/Bub2/Cdc16 domain family member 15
    NP_001139685.2
    NP_001139686.2
    NP_001372777.1
    NP_001372778.1
    NP_001372779.1
    NP_001372780.1
    NP_001372781.1
    NP_001372782.1
    NP_001372783.1
    NP_073608.4
    XP_006719627.1
    XP_011536981.1
    XP_011536983.1
    XP_047285318.1
    XP_047285319.1
    XP_047285320.1
    XP_047285321.1
    XP_047285322.1
    XP_054228887.1
    XP_054228888.1
    XP_054228889.1
    XP_054228890.1
    XP_054228891.1
    XP_054228892.1
    XP_054228893.1
    XP_054228894.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146213.3NP_001139685.2  TBC1 domain family member 15 isoform 3

      See identical proteins and their annotated locations for NP_001139685.2

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Consensus CDS
      CCDS53814.1
      UniProtKB/Swiss-Prot
      Q8TC07
      Related
      ENSP00000420678.2, ENST00000485960.7
      Conserved Domains (2) summary
      pfam12068
      Location:8224
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:326561
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    2. NM_001146214.3NP_001139686.2  TBC1 domain family member 15 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Related
      ENSP00000318262.6, ENST00000319106.12
      Conserved Domains (2) summary
      smart00164
      Location:227462
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:24112
      DUF3548; Domain of unknown function (DUF3548)
    3. NM_001385848.1NP_001372777.1  TBC1 domain family member 15 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      smart00164
      Location:326559
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:10211
      DUF3548; Domain of unknown function (DUF3548)
    4. NM_001385849.1NP_001372778.1  TBC1 domain family member 15 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      smart00164
      Location:315550
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:10211
      DUF3548; Domain of unknown function (DUF3548)
    5. NM_001385850.1NP_001372779.1  TBC1 domain family member 15 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      smart00164
      Location:326541
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:10211
      DUF3548; Domain of unknown function (DUF3548)
    6. NM_001385851.1NP_001372780.1  TBC1 domain family member 15 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      pfam12068
      Location:10211
      DUF3548; Domain of unknown function (DUF3548)
      cl02495
      Location:326539
      RabGAP-TBC; Rab-GTPase-TBC domain
    7. NM_001385852.1NP_001372781.1  TBC1 domain family member 15 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      smart00164
      Location:301536
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:10186
      DUF3548; Domain of unknown function (DUF3548)
    8. NM_001385853.1NP_001372782.1  TBC1 domain family member 15 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      smart00164
      Location:326522
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:10211
      DUF3548; Domain of unknown function (DUF3548)
    9. NM_001385854.1NP_001372783.1  TBC1 domain family member 15 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Conserved Domains (2) summary
      smart00164
      Location:268503
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12068
      Location:4153
      DUF3548; Domain of unknown function (DUF3548)
    10. NM_022771.6NP_073608.4  TBC1 domain family member 15 isoform 1

      See identical proteins and their annotated locations for NP_073608.4

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
      Consensus CDS
      CCDS31858.1
      UniProtKB/Swiss-Prot
      B4DMT9, B9A6L6, J3KNI9, Q8TC07, Q9HA83
      Related
      ENSP00000448182.1, ENST00000550746.5
      Conserved Domains (2) summary
      pfam12068
      Location:8219
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:343578
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RNA

    1. NR_027449.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    2. NR_169765.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    3. NR_169766.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    4. NR_169767.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    5. NR_169768.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    6. NR_169769.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    7. NR_169770.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    8. NR_169771.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    9. NR_169772.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    10. NR_169773.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    11. NR_169774.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    12. NR_169775.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    13. NR_169776.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    14. NR_169777.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    15. NR_169778.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    16. NR_169779.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    17. NR_169780.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    18. NR_169781.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    19. NR_169782.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    20. NR_169783.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    21. NR_169784.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    22. NR_169785.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    23. NR_169786.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    24. NR_169787.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    25. NR_169788.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109
    26. NR_169789.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089984, AC090109

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      71839759..71924313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538679.1XP_011536981.1  TBC1 domain family member 15 isoform X4

      See identical proteins and their annotated locations for XP_011536981.1

      Conserved Domains (2) summary
      pfam12068
      Location:1120
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:244479
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    2. XM_047429362.1XP_047285318.1  TBC1 domain family member 15 isoform X2

    3. XM_047429363.1XP_047285319.1  TBC1 domain family member 15 isoform X3

    4. XM_047429364.1XP_047285320.1  TBC1 domain family member 15 isoform X4

    5. XM_011538681.4XP_011536983.1  TBC1 domain family member 15 isoform X5

      Conserved Domains (2) summary
      pfam12068
      Location:8219
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:343453
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    6. XM_047429365.1XP_047285321.1  TBC1 domain family member 15 isoform X6

    7. XM_006719564.3XP_006719627.1  TBC1 domain family member 15 isoform X1

      Conserved Domains (2) summary
      pfam12068
      Location:19227
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:351586
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    8. XM_047429366.1XP_047285322.1  TBC1 domain family member 15 isoform X7

      UniProtKB/TrEMBL
      A8K8E1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      71817237..71901791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372916.1XP_054228891.1  TBC1 domain family member 15 isoform X4

    2. XM_054372913.1XP_054228888.1  TBC1 domain family member 15 isoform X2

    3. XM_054372914.1XP_054228889.1  TBC1 domain family member 15 isoform X3

    4. XM_054372915.1XP_054228890.1  TBC1 domain family member 15 isoform X4

    5. XM_054372917.1XP_054228892.1  TBC1 domain family member 15 isoform X5

    6. XM_054372918.1XP_054228893.1  TBC1 domain family member 15 isoform X6

    7. XM_054372912.1XP_054228887.1  TBC1 domain family member 15 isoform X1

    8. XM_054372919.1XP_054228894.1  TBC1 domain family member 15 isoform X7

      UniProtKB/TrEMBL
      A8K8E1