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    GORASP1 golgi reassembly stacking protein 1 [ Homo sapiens (human) ]

    Gene ID: 64689, updated on 23-Nov-2021

    Summary

    Official Symbol
    GORASP1provided by HGNC
    Official Full Name
    golgi reassembly stacking protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16769
    See related
    Ensembl:ENSG00000114745 MIM:606867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P65; GOLPH5; GRASP65
    Summary
    The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in testis (RPKM 12.9), brain (RPKM 12.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GORASP1 in Genome Data Viewer
    Location:
    3p22.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (39096599..39107843, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39138090..39149118, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986042 Neighboring gene sodium voltage-gated channel alpha subunit 11 Neighboring gene RNA, U6 small nuclear 1227, pseudogene Neighboring gene WD repeat domain 48 Neighboring gene tetratricopeptide repeat domain 21A Neighboring gene uncharacterized LOC101928263 Neighboring gene microRNA 6822 Neighboring gene cysteine and serine rich nuclear protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23443, MGC118894, MGC118897

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    Golgi reassembly-stacking protein 1
    Names
    Golgi peripheral membrane protein p65
    Golgi phosphoprotein 5
    Golgi reassembly and stacking protein 1
    golgi reassembly stacking protein 1, 65kDa
    golgi reassembly-stacking protein of 65 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278789.2NP_001265718.1  Golgi reassembly-stacking protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001265718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
      Source sequence(s)
      AI824080, AK001574, AK057043, AK124755, AK303847
      Consensus CDS
      CCDS63597.1
      UniProtKB/Swiss-Prot
      Q9BQQ3
      UniProtKB/TrEMBL
      B3KPY8, B4E1H8
      Related
      ENSP00000419123.1, ENST00000479927.5
      Conserved Domains (2) summary
      cl00117
      Location:3110
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cl27544
      Location:99203
      Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain
    2. NM_001278790.2NP_001265719.1  Golgi reassembly-stacking protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001265719.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons and uses an alternate splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks two internal segments and is shorter than isoform 1.
      Source sequence(s)
      AI824080, AK057043, BC008928
      Consensus CDS
      CCDS63596.1
      UniProtKB/Swiss-Prot
      Q9BQQ3
      UniProtKB/TrEMBL
      B3KPY8
      Related
      ENSP00000395709.2, ENST00000422110.6
      Conserved Domains (1) summary
      cl00117
      Location:350
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    3. NM_031899.4NP_114105.1  Golgi reassembly-stacking protein 1 isoform 1

      See identical proteins and their annotated locations for NP_114105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI824080, AK001574, AK057043, AK124755
      Consensus CDS
      CCDS2681.1
      UniProtKB/Swiss-Prot
      Q9BQQ3
      UniProtKB/TrEMBL
      A0A024R2U5, B3KPY8
      Related
      ENSP00000313869.3, ENST00000319283.8
      Conserved Domains (3) summary
      pfam04495
      Location:69205
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:3100
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cl27544
      Location:194298
      Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain

    RNA

    1. NR_103866.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI824080, AK124755, BC008928, BM470731, DB031221
      Related
      ENST00000452389.6
    2. NR_103867.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI824080, AK057043, BC064624
      Related
      ENST00000453680.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      39096599..39107843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713301.4XP_006713364.1  Golgi reassembly-stacking protein 1 isoform X1

      Conserved Domains (2) summary
      pfam04495
      Location:74210
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:26105
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    2. XM_017007051.2XP_016862540.1  Golgi reassembly-stacking protein 1 isoform X5

      Conserved Domains (1) summary
      cl00117
      Location:69145
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    3. XM_017007050.2XP_016862539.1  Golgi reassembly-stacking protein 1 isoform X3

      Conserved Domains (2) summary
      pfam04495
      Location:69175
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:3100
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    4. XM_017007052.2XP_016862541.1  Golgi reassembly-stacking protein 1 isoform X6

      Related
      ENST00000441302.6
    5. XM_024453714.1XP_024309482.1  Golgi reassembly-stacking protein 1 isoform X7

      Conserved Domains (2) summary
      cl00117
      Location:635
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cl27544
      Location:36128
      Herpes_glycop_D; Herpesvirus glycoprotein D/GG/GX domain
    6. XM_011534021.3XP_011532323.1  Golgi reassembly-stacking protein 1 isoform X4

      Conserved Domains (1) summary
      cl00117
      Location:74150
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    7. XM_011534020.3XP_011532322.1  Golgi reassembly-stacking protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04495
      Location:74180
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:26105
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RNA

    1. XR_940493.3 RNA Sequence

    2. XR_002959572.1 RNA Sequence

    3. XR_002959570.1 RNA Sequence

    4. XR_002959573.1 RNA Sequence

    5. XR_002959571.1 RNA Sequence

    6. XR_002959569.1 RNA Sequence

    7. XR_940494.3 RNA Sequence

    8. XR_001740235.2 RNA Sequence

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