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    EBF2 EBF transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 64641, updated on 17-Jun-2019

    Summary

    Official Symbol
    EBF2provided by HGNC
    Official Full Name
    EBF transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:19090
    See related
    Ensembl:ENSG00000221818 MIM:609934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COE2; OE-3; EBF-2; O/E-3
    Summary
    The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
    Expression
    Biased expression in fat (RPKM 8.6), heart (RPKM 4.4) and 7 other tissues See more
    Orthologs

    Genomic context

    See EBF2 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (25841725..26045413, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25699246..25902640, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986933 Neighboring gene uncharacterized LOC105379333 Neighboring gene uncharacterized LOC105379332 Neighboring gene uncharacterized LOC102723395 Neighboring gene uncharacterized LOC105379335 Neighboring gene uncharacterized LOC105379336 Neighboring gene RNA, 5S ribosomal pseudogene 258

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11500

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor COE2
    Names
    Collier, Olf and EBF 2
    Collier, Olf and EBF transcription factor 2
    OLF-1/EBF-LIKE 3
    early B cell factor 2
    metencephalon-mesencephalnon-olfactory transcription factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030344.1 RefSeqGene

      Range
      5001..208395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022659.4NP_073150.2  transcription factor COE2

      See identical proteins and their annotated locations for NP_073150.2

      Status: REVIEWED

      Source sequence(s)
      AC023566, AC090103, AI457889, AK021562, AK093878, AK304372, BC137106, BQ878633, BY798905
      Consensus CDS
      CCDS43726.1
      UniProtKB/Swiss-Prot
      Q9HAK2
      UniProtKB/TrEMBL
      B2RNT0, B7Z934
      Related
      ENSP00000430241.1, ENST00000520164.6
      Conserved Domains (3) summary
      cd01175
      Location:253337
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:20246
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:338381
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      25841725..26045413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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