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    SGK1 serum/glucocorticoid regulated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6446, updated on 17-Jun-2019

    Summary

    Official Symbol
    SGK1provided by HGNC
    Official Full Name
    serum/glucocorticoid regulated kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:10810
    See related
    Ensembl:ENSG00000118515 MIM:602958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGK
    Summary
    This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in small intestine (RPKM 111.9), gall bladder (RPKM 85.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See SGK1 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (134169246..134318112, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134490384..134639196, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene Neighboring gene uncharacterized LOC107986646 Neighboring gene ribosomal protein S29 pseudogene 32 Neighboring gene RNA, 5S ribosomal pseudogene 218 Neighboring gene keratin 8 pseudogene 42 Neighboring gene uncharacterized LOC105378009 Neighboring gene SGK1-CHCHD2P4 intergenic CAGE-defined mid-level expression enhancer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    NHGRI GWA Catalog
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    NHGRI GWA Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies serum/glucocorticoid regulated kinase SGK1 is important for HIV-1 replication PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
      Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
    • Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
      Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
    • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events, organism-specific biosystem
      Class I PI3K signaling events
    • Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
      Insulin Pathway, organism-specific biosystem
      Insulin Pathway
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
      MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Degradation, organism-specific biosystemIn unstressed cells, TP53 (p53) has a short half-life as it undergoes rapid ubiquitination and proteasome-mediated degradation. The E3 ubiquitin ligase MDM2, which is a transcriptional target of TP53...
    • Regulation of TP53 Expression and Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Expression and Degradation, organism-specific biosystemTP53 (p53) tumor suppressor protein is a transcription factor that functions as a homotetramer (Jeffrey et al. 1995). The protein levels of TP53 are low in unstressed cells due to MDM2-mediated ubiqu...
    • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
      Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    chloride channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    potassium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    long-term memory TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of catalytic activity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gastric acid secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    renal sodium ion absorption TAS
    Traceable Author Statement
    more info
    PubMed 
    sodium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Sgk1
    Names
    Sgk1 variant i3
    serine/threonine protein kinase SGK
    NP_001137148.1
    NP_001137149.1
    NP_001137150.1
    NP_001278924.1
    NP_005618.2
    XP_011534373.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143676.1NP_001137148.1  serine/threonine-protein kinase Sgk1 isoform 2

      See identical proteins and their annotated locations for NP_001137148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane.
      Source sequence(s)
      AK055077, BP384292, EU518415
      Consensus CDS
      CCDS47476.1
      UniProtKB/Swiss-Prot
      O00141
      Related
      ENSP00000356832.5, ENST00000367858.9
      Conserved Domains (2) summary
      smart00220
      Location:193450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05575
      Location:197519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
    2. NM_001143677.2NP_001137149.1  serine/threonine-protein kinase Sgk1 isoform 3

      See identical proteins and their annotated locations for NP_001137149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (3) with a longer and an unique N-terminus compared to isoform 1.
      Source sequence(s)
      AK098509, BP384292, DA309338
      Consensus CDS
      CCDS47477.1
      UniProtKB/Swiss-Prot
      O00141
      Related
      ENSP00000434450.1, ENST00000528577.5
      Conserved Domains (1) summary
      cd05575
      Location:130452
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
    3. NM_001143678.2NP_001137150.1  serine/threonine-protein kinase Sgk1 isoform 4

      See identical proteins and their annotated locations for NP_001137150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (4) with a longer and an unique N-terminus compared to isoform 1.
      Source sequence(s)
      AK098509, BP384292, DC428953
      Consensus CDS
      CCDS47478.1
      UniProtKB/Swiss-Prot
      O00141
      Related
      ENSP00000396242.3, ENST00000413996.7
      Conserved Domains (1) summary
      cd05602
      Location:104442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
    4. NM_001291995.2NP_001278924.1  serine/threonine-protein kinase Sgk1 isoform 5

      See identical proteins and their annotated locations for NP_001278924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF153609, AK295422, DB450096
      Consensus CDS
      CCDS78184.1
      UniProtKB/Swiss-Prot
      O00141
      UniProtKB/TrEMBL
      B7Z325, E9PR89
      Related
      ENSP00000434302.1, ENST00000475719.6
      Conserved Domains (1) summary
      cl21453
      Location:90384
      PKc_like; Protein Kinases, catalytic domain
    5. NM_005627.4NP_005618.2  serine/threonine-protein kinase Sgk1 isoform 1

      See identical proteins and their annotated locations for NP_005618.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AK098509, BP384292, DB450096
      Consensus CDS
      CCDS5170.1
      UniProtKB/Swiss-Prot
      O00141
      Related
      ENSP00000237305.7, ENST00000237305.11
      Conserved Domains (1) summary
      cd05602
      Location:90428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      134169246..134318112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536071.1XP_011534373.1  serine/threonine-protein kinase Sgk1 isoform X1

      See identical proteins and their annotated locations for XP_011534373.1

      UniProtKB/Swiss-Prot
      O00141
      Conserved Domains (2) summary
      smart00220
      Location:193450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05575
      Location:197519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
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