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    NFKBIZ NFKB inhibitor zeta [ Homo sapiens (human) ]

    Gene ID: 64332, updated on 17-Jun-2019

    Summary

    Official Symbol
    NFKBIZprovided by HGNC
    Official Full Name
    NFKB inhibitor zetaprovided by HGNC
    Primary source
    HGNC:HGNC:29805
    See related
    Ensembl:ENSG00000144802 MIM:608004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IKBZ; INAP; MAIL
    Summary
    This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 120.3), urinary bladder (RPKM 31.0) and 18 other tissues See more
    Orthologs

    Genomic context

    See NFKBIZ in Genome Data Viewer
    Location:
    3q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (101827990..101861022)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101546834..101579869)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene centrosomal protein 97 Neighboring gene Sharpr-MPRA regulatory region 11 Neighboring gene neurexophilin and PC-esterase domain family member 3 Neighboring gene Sharpr-MPRA regulatory region 7874 Neighboring gene long intergenic non-protein coding RNA 2085 Neighboring gene uncharacterized LOC101929411

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ) in primary human brain microvascular endothelial cells PubMed
    tat HIV-1 Tat upregulates the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ30225, FLJ34463

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T-helper 17 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    NF-kappa-B inhibitor zeta
    Names
    I-kappa-B-zeta
    IL-1 inducible nuclear ankyrin-repeat protein
    Ikappa B-zeta variant 3
    IkappaB-zeta
    ikB-zeta
    ikappaBzeta
    molecule possessing ankyrin repeats induced by lipopolysaccharide
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005474.3NP_001005474.1  NF-kappa-B inhibitor zeta isoform b

      See identical proteins and their annotated locations for NP_001005474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains alternative 5' non-coding exons compared to variant 1, and initiates translation from an in-frame downstream AUG, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AF548362, AW004900, BC014587, BX492097, DA541852
      Consensus CDS
      CCDS43123.1
      UniProtKB/Swiss-Prot
      Q9BYH8
      Related
      ENSP00000377618.2, ENST00000394054.6
      Conserved Domains (4) summary
      cd00204
      Location:407573
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:348436
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:498556
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:451509
      ANK; ANK repeat [structural motif]
    2. NM_031419.4NP_113607.1  NF-kappa-B inhibitor zeta isoform a

      See identical proteins and their annotated locations for NP_113607.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      BC014587, BC060800
      Consensus CDS
      CCDS2946.1
      UniProtKB/Swiss-Prot
      Q9BYH8
      Related
      ENSP00000325663.5, ENST00000326172.9
      Conserved Domains (4) summary
      cd00204
      Location:507673
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:448536
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:598656
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:551609
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      101827990..101861022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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