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    Bcat2 branched chain amino acid transaminase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64203, updated on 18-Apr-2019

    Summary

    Official Symbol
    Bcat2provided by RGD
    Official Full Name
    branched chain amino acid transaminase 2provided by RGD
    Primary source
    RGD:68948
    See related
    Ensembl:ENSRNOG00000020956
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BCT2; Bcatm; mBcat
    Summary
    mitochondrial branched-chain-amino-acid transaminase [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 209.9), Kidney (RPKM 172.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Bcat2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101553900..101572103)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (102633422..102650883)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A4 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene uncharacterized LOC102556190 Neighboring gene fibroblast growth factor 21 Neighboring gene fucosyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    L-isoleucine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-leucine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-valine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    branched-chain-amino-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branched-chain-amino-acid transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    branched-chain amino acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branched-chain amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    branched-chain amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    branched-chain amino acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    isoleucine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    isoleucine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    isoleucine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    isoleucine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leucine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leucine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    leucine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of hormone levels IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of hormone levels ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    valine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    valine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    branched-chain-amino-acid aminotransferase, mitochondrial
    Names
    BCAT(m)
    branched chain amino acid transaminase 2, mitochondrial
    branched chain aminotransferase 2, mitochondrial
    heart branched chain aminotransferase precursor encoding mitochondrial protein
    NP_071795.1
    XP_006229211.1
    XP_008757635.1
    XP_017445146.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022400.1NP_071795.1  branched-chain-amino-acid aminotransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_071795.1

      Status: PROVISIONAL

      Source sequence(s)
      U68417
      UniProtKB/Swiss-Prot
      O35854
      Related
      ENSRNOP00000028474.3, ENSRNOT00000028474.5
      Conserved Domains (2) summary
      PRK13357
      Location:42393
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:88383
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      101553900..101572103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759413.1XP_008757635.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008757635.1

      UniProtKB/TrEMBL
      Q6P784
      Conserved Domains (2) summary
      PRK13357
      Location:42388
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:88378
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    2. XM_017589657.1XP_017445146.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

      Conserved Domains (2) summary
      PRK13357
      Location:1329
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:24319
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    3. XM_006229149.1XP_006229211.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006229211.1

      Conserved Domains (2) summary
      PRK13357
      Location:1329
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:24319
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      90298174..90315510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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