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    TMEM91 transmembrane protein 91 [ Homo sapiens (human) ]

    Gene ID: 641649, updated on 17-Jun-2019

    Summary

    Official Symbol
    TMEM91provided by HGNC
    Official Full Name
    transmembrane protein 91provided by HGNC
    Primary source
    HGNC:HGNC:32393
    See related
    Ensembl:ENSG00000142046 MIM:618294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSPC3; IFITMD6
    Expression
    Broad expression in bone marrow (RPKM 6.3), testis (RPKM 5.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See TMEM91 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41363947..41384083)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41856873..41889988)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97 Neighboring gene transforming growth factor beta 1 Neighboring gene B9 domain containing 2 Neighboring gene exosome component 5 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: BCKDHA

    Homology

    Clone Names

    • FLJ27310, FLJ45695

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 91
    Names
    dispanin subfamily C member 3
    interferon induced transmembrane protein domain containing 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042595.2NP_001036060.1  transmembrane protein 91 isoform b

      See identical proteins and their annotated locations for NP_001036060.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 7 both encode the same isoform (b).
      Source sequence(s)
      AI214374, AI277187, BC063705, BG697182
      Consensus CDS
      CCDS42572.1
      UniProtKB/Swiss-Prot
      Q6ZNR0
      Related
      ENSP00000348750.4, ENST00000356385.8
      Conserved Domains (1) summary
      pfam04505
      Location:92120
      CD225; Interferon-induced transmembrane protein
    2. NM_001098821.2NP_001092291.1  transmembrane protein 91 isoform a

      See identical proteins and their annotated locations for NP_001092291.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a).
      Source sequence(s)
      AI214374, AK130820, DA673235
      Consensus CDS
      CCDS42571.1
      UniProtKB/Swiss-Prot
      Q6ZNR0
      Related
      ENSP00000375859.1, ENST00000392002.7
      Conserved Domains (1) summary
      pfam04505
      Location:92157
      CD225; Interferon-induced transmembrane protein
    3. NM_001098822.1NP_001092292.1  transmembrane protein 91 isoform c

      See identical proteins and their annotated locations for NP_001092292.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 6, and 8 all encode the same isoform (c).
      Source sequence(s)
      BX090160, DA673235, R67551
      Consensus CDS
      CCDS46082.1
      UniProtKB/Swiss-Prot
      Q6ZNR0
      Related
      ENSP00000437779.1, ENST00000544232.5
      Conserved Domains (1) summary
      pfam04505
      Location:92124
      CD225; Interferon-induced transmembrane protein
    4. NM_001098823.1NP_001092293.1  transmembrane protein 91 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI214374, BF684543, DA673235
      Consensus CDS
      CCDS46083.1
      UniProtKB/Swiss-Prot
      Q6ZNR0
      Related
      ENSP00000405647.2, ENST00000447302.6
      Conserved Domains (1) summary
      pfam04505
      Location:92120
      CD225; Interferon-induced transmembrane protein
    5. NM_001098824.1NP_001092294.1  transmembrane protein 91 isoform e

      See identical proteins and their annotated locations for NP_001092294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform e) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      BM675470, BM931402, DA673235
      Consensus CDS
      CCDS46084.1
      UniProtKB/Swiss-Prot
      Q6ZNR0
      Related
      ENSP00000407003.2, ENST00000436170.6
      Conserved Domains (1) summary
      pfam04505
      Location:92120
      CD225; Interferon-induced transmembrane protein
    6. NM_001098825.1NP_001092295.1  transmembrane protein 91 isoform c

      See identical proteins and their annotated locations for NP_001092295.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 6, and 8 all encode the same isoform (c).
      Source sequence(s)
      AI214374, BM726200, R01772
      Consensus CDS
      CCDS46082.1
      UniProtKB/Swiss-Prot
      Q6ZNR0
      Related
      ENSP00000413192.2, ENST00000413014.6
      Conserved Domains (1) summary
      pfam04505
      Location:92124
      CD225; Interferon-induced transmembrane protein
    7. NM_001369862.1NP_001356791.1  transmembrane protein 91 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC011462
    8. NM_001369864.1NP_001356793.1  transmembrane protein 91 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 3 and 6, encodes isoform c.
      Source sequence(s)
      AC011462

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41363947..41384083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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