U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    KIF9 kinesin family member 9 [ Homo sapiens (human) ]

    Gene ID: 64147, updated on 6-Jun-2024

    Summary

    Official Symbol
    KIF9provided by HGNC
    Official Full Name
    kinesin family member 9provided by HGNC
    Primary source
    HGNC:HGNC:16666
    See related
    Ensembl:ENSG00000088727 MIM:607910; AllianceGenome:HGNC:16666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables identical protein binding activity. Involved in extracellular matrix disassembly; organelle disassembly; and regulation of podosome assembly. Located in microtubule; podosome; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 11.7), thyroid (RPKM 1.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF9 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (47227998..47282799, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (47244385..47299181, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47269488..47324289, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47082829-47083038 Neighboring gene mitochondrial ribosomal protein L57 pseudogene 3 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47108907-47109512 Neighboring gene NANOG hESC enhancer GRCh37_chr3:47125242-47125743 Neighboring gene uncharacterized LOC124906375 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155200-47155707 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47155708-47156216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19809 Neighboring gene KIF9 antisense RNA 1 Neighboring gene MPRA-validated peak4632 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47238926-47239426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:47301362-47302268 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 13J Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:47323613-47324812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14308 Neighboring gene kelch like family member 18 Neighboring gene Sharpr-MPRA regulatory region 13740 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:47403837-47405036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47421897-47422574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:47422575-47423250 Neighboring gene PTPN23 divergent transcript Neighboring gene protein tyrosine phosphatase non-receptor type 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104186

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in organelle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF9
    Names
    kinesin protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134878.3NP_001128350.1  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_001128350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate in-frame exon in the mid coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC104447, AI741745, AK292547, AK314418
      Consensus CDS
      CCDS2752.1
      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000391100.2, ENST00000452770.6
      Conserved Domains (2) summary
      cd01375
      Location:6338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12340
      Kinesin; Kinesin motor domain
    2. NM_001377474.1NP_001364403.1  kinesin-like protein KIF9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (1) summary
      cl22853
      Location:6263
      Motor_domain; Myosin and Kinesin motor domain
    3. NM_001377475.1NP_001364404.1  kinesin-like protein KIF9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (1) summary
      cl22853
      Location:6263
      Motor_domain; Myosin and Kinesin motor domain
    4. NM_001377476.1NP_001364405.1  kinesin-like protein KIF9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104447
      Consensus CDS
      CCDS93262.1
      UniProtKB/TrEMBL
      E7EUW8, Q6PJI1
      Related
      ENSP00000391099.1, ENST00000432493.5
      Conserved Domains (1) summary
      cl22853
      Location:689
      Motor_domain; Myosin and Kinesin motor domain
    5. NM_001377477.1NP_001364406.1  kinesin-like protein KIF9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104447
      Consensus CDS
      CCDS93262.1
      UniProtKB/TrEMBL
      E7EUW8, Q6PJI1
      Related
      ENSP00000406815.1, ENST00000425853.5
      Conserved Domains (1) summary
      cl22853
      Location:689
      Motor_domain; Myosin and Kinesin motor domain
    6. NM_001413975.1NP_001400904.1  kinesin-like protein KIF9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
    7. NM_001413976.1NP_001400905.1  kinesin-like protein KIF9 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC104447
      UniProtKB/TrEMBL
      A8K932
    8. NM_022342.6NP_071737.1  kinesin-like protein KIF9 isoform 1

      See identical proteins and their annotated locations for NP_071737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AC104447, AF311212, AI741745, AK292547
      Consensus CDS
      CCDS2751.1
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000414987.2, ENST00000444589.6
      Conserved Domains (2) summary
      cd01375
      Location:6338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12340
      Kinesin; Kinesin motor domain
    9. NM_182902.4NP_878905.2  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_878905.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the mid coding region, compared to variant 1, and encodes an isoform (2) that is longer than isoform 1. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC104447, AI741745, AK292547, AK314418, BC030657
      Consensus CDS
      CCDS2752.1
      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Related
      ENSP00000507186.1, ENST00000684063.1
      Conserved Domains (2) summary
      cd01375
      Location:6338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12340
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      47227998..47282799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448712.1XP_047304668.1  kinesin-like protein KIF9 isoform X6

      UniProtKB/TrEMBL
      A8K932
    2. XM_006713291.4XP_006713354.1  kinesin-like protein KIF9 isoform X4

      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cl22853
      Location:39296
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:45298
      Kinesin; Kinesin motor domain
    3. XM_005265389.5XP_005265446.1  kinesin-like protein KIF9 isoform X2

      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cd01375
      Location:39371
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:45373
      Kinesin; Kinesin motor domain
    4. XM_047448709.1XP_047304665.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
    5. XM_017007029.2XP_016862518.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/Swiss-Prot
      Q86Z28, Q9H8A4, Q9HAQ2
      UniProtKB/TrEMBL
      A8K932
      Conserved Domains (2) summary
      cd01375
      Location:6338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12340
      Kinesin; Kinesin motor domain
    6. XM_047448711.1XP_047304667.1  kinesin-like protein KIF9 isoform X5

      UniProtKB/TrEMBL
      A8K932
    7. XM_011534007.3XP_011532309.1  kinesin-like protein KIF9 isoform X8

    8. XM_047448710.1XP_047304666.1  kinesin-like protein KIF9 isoform X3

      UniProtKB/TrEMBL
      A8K932
    9. XM_047448713.1XP_047304669.1  kinesin-like protein KIF9 isoform X7

      UniProtKB/TrEMBL
      B4DXP8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      47244385..47299181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347531.1XP_054203506.1  kinesin-like protein KIF9 isoform X6

      UniProtKB/TrEMBL
      A8K932
    2. XM_054347529.1XP_054203504.1  kinesin-like protein KIF9 isoform X4

      UniProtKB/TrEMBL
      A8K932
    3. XM_054347527.1XP_054203502.1  kinesin-like protein KIF9 isoform X2

      UniProtKB/TrEMBL
      A8K932
    4. XM_054347525.1XP_054203500.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/TrEMBL
      A8K932
    5. XM_054347526.1XP_054203501.1  kinesin-like protein KIF9 isoform X1

      UniProtKB/TrEMBL
      A8K932
    6. XM_054347530.1XP_054203505.1  kinesin-like protein KIF9 isoform X5

      UniProtKB/TrEMBL
      A8K932
    7. XM_054347533.1XP_054203508.1  kinesin-like protein KIF9 isoform X8

    8. XM_054347528.1XP_054203503.1  kinesin-like protein KIF9 isoform X3

      UniProtKB/TrEMBL
      A8K932
    9. XM_054347532.1XP_054203507.1  kinesin-like protein KIF9 isoform X7

      UniProtKB/TrEMBL
      B4DXP8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182903.2: Suppressed sequence

      Description
      NM_182903.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.