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    SELENOP selenoprotein P [ Homo sapiens (human) ]

    Gene ID: 6414, updated on 18-Jun-2019

    Summary

    Official Symbol
    SELENOPprovided by HGNC
    Official Full Name
    selenoprotein Pprovided by HGNC
    Primary source
    HGNC:HGNC:10751
    See related
    Ensembl:ENSG00000250722 MIM:601484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SeP; SELP; SEPP; SEPP1
    Summary
    This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
    Expression
    Broad expression in liver (RPKM 1192.8), small intestine (RPKM 1057.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See SELENOP in Genome Data Viewer
    Location:
    5p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (42799880..42812076, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (42799982..42812024, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 35 pseudogene Neighboring gene growth hormone receptor Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 6 Neighboring gene GHR downstream promoter region module B Neighboring gene coiled-coil domain containing 152 Neighboring gene PRELI domain containing 3B pseudogene 4 Neighboring gene peptidylprolyl isomerase A pseudogene 77

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of selenoprotein P (SEPP1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • Selenium Metabolism and Selenoproteins, organism-specific biosystem (from WikiPathways)
      Selenium Metabolism and Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...
    • Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
      Selenium Micronutrient Network, organism-specific biosystem
      Selenium Micronutrient Network

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    selenium binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    response to selenium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    selenium compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sexual reproduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet dense granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    selenoprotein P
    Names
    selenoprotein P, plasma, 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085486.2NP_001078955.1  selenoprotein P isoform 1 precursor

      See identical proteins and their annotated locations for NP_001078955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Sepp1c) contains an additional 5' non-coding exon, and thus has a different and longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      DA288385, HM005482
      Consensus CDS
      CCDS43311.1
      UniProtKB/Swiss-Prot
      P49908
      Related
      ENSP00000427671.1, ENST00000511224.5
      Conserved Domains (2) summary
      pfam04592
      Location:23243
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:251381
      SelP_C; Selenoprotein P, C terminal region
    2. NM_001093726.2NP_001087195.1  selenoprotein P isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Sepp1b) contains an additional 5' coding exon compared to variant 1. It initiates translation from an in-frame, upstream start codon, which results in an isoform (2) with a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL599162, BC040075, DA288385, HM005482
      UniProtKB/Swiss-Prot
      P49908
      Conserved Domains (2) summary
      pfam04592
      Location:53273
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:281411
      SelP_C; Selenoprotein P, C terminal region
    3. NM_005410.4NP_005401.3  selenoprotein P isoform 1 precursor

      See identical proteins and their annotated locations for NP_005401.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC040075, DA288385, HM005482
      Consensus CDS
      CCDS43311.1
      UniProtKB/Swiss-Prot
      P49908
      Related
      ENSP00000420939.1, ENST00000514985.6
      Conserved Domains (2) summary
      pfam04592
      Location:23243
      SelP_N; Selenoprotein P, N terminal region
      pfam04593
      Location:251381
      SelP_C; Selenoprotein P, C terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      42799880..42812076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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