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    RTP4 receptor transporter protein 4 [ Homo sapiens (human) ]

    Gene ID: 64108, updated on 15-Jun-2019

    Summary

    Official Symbol
    RTP4provided by HGNC
    Official Full Name
    receptor transporter protein 4provided by HGNC
    Primary source
    HGNC:HGNC:23992
    See related
    Ensembl:ENSG00000136514 MIM:609350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFRG28; Z3CXXC4
    Expression
    Ubiquitous expression in urinary bladder (RPKM 8.4), duodenum (RPKM 6.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See RTP4 in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (187368380..187371584)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187086168..187089372)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mannan binding lectin serine peptidase 1 Neighboring gene MASP1 intron CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC101929130 Neighboring gene long intergenic non-protein coding RNA 2041 Neighboring gene uncharacterized LOC105374262

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
      Olfactory Signaling Pathway, organism-specific biosystemMammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) th...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    olfactory receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of chemical stimulus involved in sensory perception of bitter taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein insertion into membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    receptor-transporting protein 4
    Names
    28 kDa interferon-responsive protein
    28kD interferon responsive protein
    3CxxC-type zinc finger protein 4
    receptor (chemosensory) transporter protein 4
    zinc finger, 3CxxC-type 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022147.3NP_071430.2  receptor-transporting protein 4

      See identical proteins and their annotated locations for NP_071430.2

      Status: VALIDATED

      Source sequence(s)
      AC068299, BC013161, CA413859
      Consensus CDS
      CCDS33910.1
      UniProtKB/Swiss-Prot
      Q96DX8
      Related
      ENSP00000259030.2, ENST00000259030.3
      Conserved Domains (1) summary
      pfam13695
      Location:48160
      zf-3CxxC; Zinc-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      187368385..187372076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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