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    CENPK centromere protein K [ Homo sapiens (human) ]

    Gene ID: 64105, updated on 8-Jul-2021

    Summary

    Official Symbol
    CENPKprovided by HGNC
    Official Full Name
    centromere protein Kprovided by HGNC
    Primary source
    HGNC:HGNC:29479
    See related
    Ensembl:ENSG00000123219 MIM:611502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P33; Solt; CENP-K; FKSG14; AF5alpha
    Summary
    CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 1.8), bone marrow (RPKM 1.7) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CENPK in Genome Data Viewer
    Location:
    5q12.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (65488919..65563194, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64812119..64858995, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 6 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 1 Neighboring gene ribosomal protein S2 pseudogene 23 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of centromere protein K (CENPK) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    centromere protein K
    Names
    SoxLZ/Sox6-binding protein Solt
    interphase centromere complex protein 37
    leucine zipper protein FKSG14
    protein AF-5alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267038.2NP_001253967.1  centromere protein K isoform 1

      See identical proteins and their annotated locations for NP_001253967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC005400, BC008504, BG502832
      Consensus CDS
      CCDS3984.1
      UniProtKB/Swiss-Prot
      Q9BS16
      Related
      ENSP00000422421.1, ENST00000514814.5
      Conserved Domains (1) summary
      pfam11802
      Location:10269
      CENP-K; Centromere-associated protein K
    2. NM_001349367.2NP_001336296.1  centromere protein K isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in its 5' coding region, resulting in use of an alternate start codon, compared to variant 1. The encoded isoform (3) has a slightly longer, but distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC005400, BC008504, BG502832, BG527280
      Conserved Domains (1) summary
      pfam11802
      Location:12271
      CENP-K; Centromere-associated protein K
    3. NM_001349368.2NP_001336297.1  centromere protein K isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and lacks an alternate in-frame exon in its central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      BC005400, BC008504, BF211376, BG502832, BG505115
      Consensus CDS
      CCDS87299.1
      Conserved Domains (1) summary
      pfam11802
      Location:1206
      CENP-K; Centromere-associated protein K
    4. NM_001349369.2NP_001336298.1  centromere protein K isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and contains an alternate terminal exon, resulting in a novel 3' coding region, compared to variant 1. The encoded isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC016620, BC005400, BG502832, BG505115
      Conserved Domains (1) summary
      pfam11802
      Location:1189
      CENP-K; Centromere-associated protein K
    5. NM_022145.5NP_071428.2  centromere protein K isoform 1

      See identical proteins and their annotated locations for NP_071428.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC008504
      Consensus CDS
      CCDS3984.1
      UniProtKB/Swiss-Prot
      Q9BS16
      Related
      ENSP00000379911.1, ENST00000396679.6
      Conserved Domains (1) summary
      pfam11802
      Location:10269
      CENP-K; Centromere-associated protein K

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      65488919..65563194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009693.1XP_016865182.1  centromere protein K isoform X3

    2. XM_017009696.2XP_016865185.1  centromere protein K isoform X9

    3. XM_011543540.2XP_011541842.1  centromere protein K isoform X8

      Conserved Domains (1) summary
      pfam11802
      Location:12221
      CENP-K; Centromere-associated protein K
    4. XM_024446144.1XP_024301912.1  centromere protein K isoform X10

      Conserved Domains (1) summary
      pfam11802
      Location:10219
      CENP-K; Centromere-associated protein K
    5. XM_017009695.1XP_016865184.1  centromere protein K isoform X6

    6. XM_011543538.2XP_011541840.1  centromere protein K isoform X5

      Conserved Domains (1) summary
      pfam11802
      Location:12238
      CENP-K; Centromere-associated protein K
    7. XM_024446148.1XP_024301916.1  centromere protein K isoform X14

      Conserved Domains (1) summary
      pfam11802
      Location:18172
      CENP-K; Centromere-associated protein K
    8. XM_011543541.2XP_011541843.1  centromere protein K isoform X12

      See identical proteins and their annotated locations for XP_011541843.1

      Conserved Domains (1) summary
      pfam11802
      Location:18205
      CENP-K; Centromere-associated protein K
    9. XM_017009697.1XP_016865186.1  centromere protein K isoform X11

    10. XM_011543537.2XP_011541839.1  centromere protein K isoform X4

      UniProtKB/TrEMBL
      D6RHD3
      Related
      ENSP00000421034.1, ENST00000508421.5
      Conserved Domains (1) summary
      pfam11802
      Location:1239
      CENP-K; Centromere-associated protein K
    11. XM_011543539.2XP_011541841.1  centromere protein K isoform X7

      Related
      ENSP00000425686.1, ENST00000510693.5
      Conserved Domains (1) summary
      pfam11802
      Location:10236
      CENP-K; Centromere-associated protein K
    12. XM_024446146.1XP_024301914.1  centromere protein K isoform X13

      Conserved Domains (1) summary
      pfam11802
      Location:4191
      CENP-K; Centromere-associated protein K
    13. XM_017009692.1XP_016865181.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16
      Conserved Domains (1) summary
      pfam11802
      Location:10269
      CENP-K; Centromere-associated protein K
    14. XM_017009690.1XP_016865179.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16
      Conserved Domains (1) summary
      pfam11802
      Location:10269
      CENP-K; Centromere-associated protein K
    15. XM_017009691.1XP_016865180.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16
      Related
      ENSP00000242872.3, ENST00000242872.7
      Conserved Domains (1) summary
      pfam11802
      Location:10269
      CENP-K; Centromere-associated protein K
    16. XM_024446145.1XP_024301913.1  centromere protein K isoform X12

      Conserved Domains (1) summary
      pfam11802
      Location:18205
      CENP-K; Centromere-associated protein K
    17. XM_024446147.1XP_024301915.1  centromere protein K isoform X13

      Conserved Domains (1) summary
      pfam11802
      Location:4191
      CENP-K; Centromere-associated protein K
    18. XM_011543542.2XP_011541844.1  centromere protein K isoform X12

      See identical proteins and their annotated locations for XP_011541844.1

      Conserved Domains (1) summary
      pfam11802
      Location:18205
      CENP-K; Centromere-associated protein K
    19. XM_011543535.2XP_011541837.1  centromere protein K isoform X1

      See identical proteins and their annotated locations for XP_011541837.1

      Conserved Domains (1) summary
      pfam11802
      Location:12271
      CENP-K; Centromere-associated protein K
    20. XM_011543536.2XP_011541838.1  centromere protein K isoform X2

      See identical proteins and their annotated locations for XP_011541838.1

      UniProtKB/Swiss-Prot
      Q9BS16
      Conserved Domains (1) summary
      pfam11802
      Location:10269
      CENP-K; Centromere-associated protein K
    21. XM_017009694.1XP_016865183.1  centromere protein K isoform X4

      UniProtKB/TrEMBL
      D6RHD3
      Conserved Domains (1) summary
      pfam11802
      Location:1239
      CENP-K; Centromere-associated protein K
    22. XM_017009701.1XP_016865190.1  centromere protein K isoform X15

    RNA

    1. XR_001742177.1 RNA Sequence

    2. XR_948282.3 RNA Sequence

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