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    Smoc1 SPARC related modular calcium binding 1 [ Mus musculus (house mouse) ]

    Gene ID: 64075, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smoc1provided by MGI
    Official Full Name
    SPARC related modular calcium binding 1provided by MGI
    Primary source
    MGI:MGI:1929878
    See related
    Ensembl:ENSMUSG00000021136 AllianceGenome:MGI:1929878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SRG; 2600002F22Rik
    Summary
    Enables extracellular matrix binding activity. Involved in eye development and limb development. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb; and sensory organ. Used to study microphthalmia with limb anomalies. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 114.5), subcutaneous fat pad adult (RPKM 35.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smoc1 in Genome Data Viewer
    Location:
    12 D1; 12 37.28 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81073582..81233188)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81026808..81186414)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5338 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr12:82083313-82083614 Neighboring gene serine and arginine-rich splicing factor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:82164637-82164838 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32668 Neighboring gene microRNA 3067 Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 3 Neighboring gene predicted gene 3693 Neighboring gene STARR-seq mESC enhancer starr_32669 Neighboring gene STARR-seq mESC enhancer starr_32670 Neighboring gene predicted gene, 53730

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties. Klemenčič M, et al. PLoS One, 2013. PMID 23437253, Free PMC Article
    2. Eye development genes and known syndromes. Slavotinek AM. Mol Genet Metab, 2011 Dec. PMID 22005280, Free PMC Article
    3. Secreted modular calcium-binding protein-1 localization during mouse embryogenesis. Gersdorff N, et al. Histochem Cell Biol, 2006 Dec. PMID 16736127
    4. Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Morkmued S, et al. Sci Rep, 2020 Sep 9. PMID 32908163, Free PMC Article
    5. Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2. Luo MJ, et al. Theranostics, 2020. PMID 32206122, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
      Title: Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
    2. Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
      Title: Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
    3. SMOC1 is an activin-like kinase antagonist produced by endothelial cells that tips TGF-beta signalling towards ALK1 activation
      Title: Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.
    4. The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties.
      Title: The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties.
    5. these findings indicate that SMOC1/Smoc1 is essential for ocular and limb development in both humans and mice.
      Title: SMOC1 is essential for ocular and limb development in humans and mice.
    6. SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
      Title: Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.
    7. expression of SMOC-1 examined in the early embryo day 7, as well as in following embryonic stages on days 12, 14, 16 & 18; broad and organ-specific distribution suggests multifunctional roles of SMOC-1 during mouse embryogenesis
      Title: Secreted modular calcium-binding protein-1 localization during mouse embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in limb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SPARC-related modular calcium-binding protein 1
    Names
    SMOC-1
    SPARC-related gene protein
    SPARC-related protein
    secreted modular calcium binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146217.1 → NP_001139689.1  SPARC-related modular calcium-binding protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001139689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124384, AK040931
      Consensus CDS
      CCDS49102.1
      UniProtKB/TrEMBL
      A0A0R4J1E4, D3Z3A3
      Related
      ENSMUSP00000105976.3, ENSMUST00000110347.9
      Conserved Domains (5) summary
      smart00280
      Location:42 → 86
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:236 → 302
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:374 → 435
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam00086
      Location:94 → 157
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:158 → 227
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

    2. NM_022316.2 → NP_071711.2  SPARC-related modular calcium-binding protein 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC124384, AK040931
      Consensus CDS
      CCDS26017.1
      UniProtKB/TrEMBL
      D3Z3A3, E9QKW2
      Related
      ENSMUSP00000021564.5, ENSMUST00000021564.11
      Conserved Domains (5) summary
      smart00280
      Location:42 → 86
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:225 → 291
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:363 → 424
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam00086
      Location:94 → 157
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:158 → 216
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81073582..81233188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516135.5 → XP_006516198.1  SPARC-related modular calcium-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      D3Z3A3
      Conserved Domains (4) summary
      cd16240
      Location:318 → 432
      EFh_SPARC_SMOC1; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 1 (SMOC-1)
      pfam00086
      Location:87 → 150
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam07648
      Location:35 → 79
      Kazal_2; Kazal-type serine protease inhibitor domain
      pfam16597
      Location:151 → 222
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLY1.2 GenPept UniProtKB/Swiss-Prot:Q8BLY1

    Gene LinkOut

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