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    C19orf33 chromosome 19 open reading frame 33 [ Homo sapiens (human) ]

    Gene ID: 64073, updated on 17-Jun-2019

    Summary

    Official Symbol
    C19orf33provided by HGNC
    Official Full Name
    chromosome 19 open reading frame 33provided by HGNC
    Primary source
    HGNC:HGNC:16668
    See related
    Ensembl:ENSG00000167644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMUP; H2RSP; IMUP-1; IMUP-2
    Summary
    The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in colon (RPKM 62.2), small intestine (RPKM 43.1) and 11 other tissues See more
    Orthologs

    Genomic context

    See C19orf33 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38304251..38305006)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38794804..38795646)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14A Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene Sharpr-MPRA regulatory region 11361 Neighboring gene cation channel sperm associated auxiliary subunit gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: SPINT2

    Homology

    Clone Names

    • MGC39135, MGC75180

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    immortalization up-regulated protein
    Names
    HAI-2 related small protein
    hepatocyte growth factor activator inhibitor type 2-related small protein
    immortalization-upregulated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317801.2NP_001304730.1  immortalization up-regulated protein isoform IMUP-2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (IMUP-2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC060319, CB109881
      Consensus CDS
      CCDS82344.1
      UniProtKB/Swiss-Prot
      Q9GZP8
      Related
      ENSP00000464940.1, ENST00000588605.5
      Conserved Domains (1) summary
      pfam15761
      Location:152
      IMUP; Immortalisation up-regulated protein
    2. NM_033520.3NP_277055.1  immortalization up-regulated protein isoform IMUP-1

      See identical proteins and their annotated locations for NP_277055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (IMUP-1).
      Source sequence(s)
      AF213678, CB109881
      Consensus CDS
      CCDS12511.1
      UniProtKB/Swiss-Prot
      Q9GZP8
      Related
      ENSP00000301246.4, ENST00000301246.10
      Conserved Domains (1) summary
      pfam15761
      Location:179
      IMUP; Immortalization up-regulated protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      38304251..38305006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022125.1: Suppressed sequence

      Description
      NM_022125.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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