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    DMRTC2 DMRT like family C2 [ Homo sapiens (human) ]

    Gene ID: 63946, updated on 17-Jun-2019

    Summary

    Official Symbol
    DMRTC2provided by HGNC
    Official Full Name
    DMRT like family C2provided by HGNC
    Primary source
    HGNC:HGNC:13911
    See related
    Ensembl:ENSG00000142025 MIM:614806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 14.6) See more
    Orthologs

    Genomic context

    See DMRTC2 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41844743..41852333)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42348806..42356398)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule 3 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52 Neighboring gene LY6/PLAUR domain containing 4 Neighboring gene ribosomal protein S19 Neighboring gene microRNA 6797 Neighboring gene CD79a molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    male meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone H3-K9 dimethylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone H3-K9 trimethylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    sex differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid nucleus elongation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    XY body IEA
    Inferred from Electronic Annotation
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    doublesex- and mab-3-related transcription factor C2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040283.3NP_001035373.1  doublesex- and mab-3-related transcription factor C2

      See identical proteins and their annotated locations for NP_001035373.1

      Status: VALIDATED

      Source sequence(s)
      AC010616, AC243967, AJ291669, DB026313
      Consensus CDS
      CCDS33034.1
      UniProtKB/Swiss-Prot
      Q8IXT2
      Related
      ENSP00000269945.2, ENST00000269945.8
      Conserved Domains (2) summary
      pfam00751
      Location:3884
      DM; DM DNA binding domain
      pfam15791
      Location:240365
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41844743..41852333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027128.1XP_016882617.1  doublesex- and mab-3-related transcription factor C2 isoform X3

      UniProtKB/TrEMBL
      B4DX56
      Conserved Domains (2) summary
      pfam00751
      Location:3884
      DM; DM DNA binding domain
      pfam15791
      Location:240416
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    2. XM_011527215.1XP_011525517.1  doublesex- and mab-3-related transcription factor C2 isoform X5

      See identical proteins and their annotated locations for XP_011525517.1

      Conserved Domains (1) summary
      pfam15791
      Location:117242
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    3. XM_017027125.1XP_016882614.1  doublesex- and mab-3-related transcription factor C2 isoform X3

      UniProtKB/TrEMBL
      B4DX56
      Related
      ENSP00000469525.1, ENST00000596827.5
      Conserved Domains (2) summary
      pfam00751
      Location:3884
      DM; DM DNA binding domain
      pfam15791
      Location:240416
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    4. XM_017027127.2XP_016882616.1  doublesex- and mab-3-related transcription factor C2 isoform X3

      UniProtKB/TrEMBL
      B4DX56
      Conserved Domains (2) summary
      pfam00751
      Location:3884
      DM; DM DNA binding domain
      pfam15791
      Location:240416
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    5. XM_011527214.1XP_011525516.1  doublesex- and mab-3-related transcription factor C2 isoform X5

      See identical proteins and their annotated locations for XP_011525516.1

      Conserved Domains (1) summary
      pfam15791
      Location:117242
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    6. XM_017027126.2XP_016882615.1  doublesex- and mab-3-related transcription factor C2 isoform X3

      UniProtKB/TrEMBL
      B4DX56
      Conserved Domains (2) summary
      pfam00751
      Location:3884
      DM; DM DNA binding domain
      pfam15791
      Location:240416
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    7. XM_011527216.2XP_011525518.1  doublesex- and mab-3-related transcription factor C2 isoform X6

      Related
      ENSP00000472159.1, ENST00000601660.5
      Conserved Domains (1) summary
      pfam00751
      Location:4389
      DM; DM DNA binding domain
    8. XM_017027123.1XP_016882612.1  doublesex- and mab-3-related transcription factor C2 isoform X1

    9. XM_017027129.1XP_016882618.1  doublesex- and mab-3-related transcription factor C2 isoform X4

    10. XM_017027124.2XP_016882613.1  doublesex- and mab-3-related transcription factor C2 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033052.1: Suppressed sequence

      Description
      NM_033052.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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