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    UBE2O ubiquitin conjugating enzyme E2 O [ Homo sapiens (human) ]

    Gene ID: 63893, updated on 17-Jun-2024

    Summary

    Official Symbol
    UBE2Oprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Oprovided by HGNC
    Primary source
    HGNC:HGNC:29554
    See related
    Ensembl:ENSG00000175931 MIM:617649; AllianceGenome:HGNC:29554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2-230K
    Summary
    Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UBE2O in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76389456..76453152, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77286031..77349733, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74385537..74449234, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74346967-74347514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9012 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74349963-74350827 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 43 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74364234-74364734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74364735-74365235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9015 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74386817-74386991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74394983-74395483 Neighboring gene sphingosine kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74418617-74419118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74419119-74419618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74429943-74430443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74432809-74433310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74437133-74437650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12806 Neighboring gene ribosomal protein L7 pseudogene 49 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9016 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74449240-74449408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12808 Neighboring gene aralkylamine N-acetyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74469380-74469890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9020 Neighboring gene Sharpr-MPRA regulatory region 10531 Neighboring gene MPRA-validated peak3008 silencer Neighboring gene rhomboid 5 homolog 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74487839-74488704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74496763-74497432

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat is identified to have a physical interaction with ubiquitin-conjugating enzyme E2O (UBE2O) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12878, KIAA1734

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    (E3-independent) E2 ubiquitin-conjugating enzyme
    Names
    E2/E3 hybrid ubiquitin-protein ligase UBE2O
    ubiquitin carrier protein O
    ubiquitin conjugating enzyme E2O
    ubiquitin-conjugating enzyme E2 of 230 kDa
    ubiquitin-conjugating enzyme E2-230K
    ubiquitin-protein ligase O
    NP_071349.3
    XP_005257624.1
    XP_016880424.1
    XP_024306633.1
    XP_024306634.1
    XP_024306635.1
    XP_047292473.1
    XP_047292474.1
    XP_054172853.1
    XP_054172854.1
    XP_054172855.1
    XP_054172856.1
    XP_054172857.1
    XP_054172858.1
    XP_054172859.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022066.4NP_071349.3  (E3-independent) E2 ubiquitin-conjugating enzyme

      See identical proteins and their annotated locations for NP_071349.3

      Status: VALIDATED

      Source sequence(s)
      AB051521, AC090699, BC025977, DA092358
      Consensus CDS
      CCDS32742.1
      UniProtKB/Swiss-Prot
      A6NDU5, Q69YP4, Q6PIZ2, Q86UA4, Q8N425, Q8TBN1, Q9BSW1, Q9C0C9, Q9H6E6, Q9H7E4, Q9H9B2
      Related
      ENSP00000323687.6, ENST00000319380.12
      Conserved Domains (1) summary
      cd00195
      Location:9581108
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76389456..76453152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024935.2XP_016880424.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X7

    2. XM_047436518.1XP_047292474.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X6

    3. XM_005257567.2XP_005257624.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X5

      See identical proteins and their annotated locations for XP_005257624.1

      Conserved Domains (1) summary
      cd00195
      Location:9591109
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    4. XM_047436517.1XP_047292473.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X4

    5. XM_024450867.2XP_024306635.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X3

      Conserved Domains (1) summary
      cd00195
      Location:9701120
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    6. XM_024450866.2XP_024306634.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X2

      Conserved Domains (1) summary
      cd00195
      Location:9941144
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    7. XM_024450865.2XP_024306633.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1

      Conserved Domains (1) summary
      cd00195
      Location:9951145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      77286031..77349733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316884.1XP_054172859.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X7

    2. XM_054316883.1XP_054172858.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X6

    3. XM_054316882.1XP_054172857.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X5

    4. XM_054316881.1XP_054172856.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X4

    5. XM_054316880.1XP_054172855.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X3

    6. XM_054316879.1XP_054172854.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X2

    7. XM_054316878.1XP_054172853.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1