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    Capn10 calpain 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63834, updated on 13-Aug-2019

    Summary

    Official Symbol
    Capn10provided by RGD
    Official Full Name
    calpain 10provided by RGD
    Primary source
    RGD:69354
    See related
    Ensembl:ENSRNOG00000045623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    large subunit of calpain, a calcium-dependent cysteine protease; human homolog has been associated with type II diabetes mellitus [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Thymus (RPKM 88.6), Adrenal (RPKM 79.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Capn10 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100104000..100112833)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (99767655..99776488)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene arginyl aminopeptidase like 1 Neighboring gene dual specificity phosphatase 28 Neighboring gene G protein-coupled receptor 35 Neighboring gene aquaporin 12A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC93346

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-dependent cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-dependent cysteine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of intracellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of type B pancreatic cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type B pancreatic cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calpain-10
    Names
    CANP 10
    calcium-activated neutral proteinase 10
    NP_113861.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031673.2NP_113861.1  calpain-10

      See identical proteins and their annotated locations for NP_113861.1

      Status: VALIDATED

      Source sequence(s)
      AF227909, BC085725
      UniProtKB/Swiss-Prot
      Q9ES66
      UniProtKB/TrEMBL
      Q5U345
      Related
      ENSRNOP00000067567.1, ENSRNOT00000074160.1
      Conserved Domains (3) summary
      smart00720
      Location:338488
      calpain_III; calpain_III domain
      cd00044
      Location:8319
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:506647
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      100104000..100112833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      91034781..91046660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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