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    CCL25 C-C motif chemokine ligand 25 [ Homo sapiens (human) ]

    Gene ID: 6370, updated on 18-Sep-2024

    Summary

    Official Symbol
    CCL25provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 25provided by HGNC
    Primary source
    HGNC:HGNC:10624
    See related
    Ensembl:ENSG00000131142 MIM:602565; AllianceGenome:HGNC:10624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TECK; Ckb15; SCYA25; TECKvar; Ck beta-15
    Summary
    This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Restricted expression toward small intestine (RPKM 203.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCL25 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8052341..8062650)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8053362..8063660)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8117225..8127534)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3325 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8033572-8034184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8034185-8034798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13905 Neighboring gene ELAV like RNA binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8042669-8043169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8066604-8067215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8067216-8067826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10008 Neighboring gene uncharacterized LOC105372266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8094053-8095028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10010 Neighboring gene fibrillin 3 Neighboring gene MPRA-validated peak3327 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8175802-8176302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8180417-8180917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8183744-8184561 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8185348-8185938 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8185939-8186529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8193691-8194192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8206295-8206796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8208101-8208645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8211691-8212662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8212663-8213633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10012 Neighboring gene Sharpr-MPRA regulatory region 3488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8226075-8226576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8228221-8229026 Neighboring gene ALG11, alpha-1,2-mannosyltransferase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC150327

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR10 chemokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chemokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 25
    Names
    chemokine (C-C motif) ligand 25
    chemokine TECK
    small inducible cytokine subfamily A (Cys-Cys), member 25
    small-inducible cytokine A25
    thymus expressed chemokine

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201359.2NP_001188288.1  C-C motif chemokine 25 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001188288.1

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS56080.1
      UniProtKB/TrEMBL
      Q08AK2
      Related
      ENSP00000253451.4, ENST00000253451.9
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    2. NM_001394634.1NP_001381563.1  C-C motif chemokine 25 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS12194.1
      UniProtKB/Swiss-Prot
      A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
      UniProtKB/TrEMBL
      C9JDZ7
      Related
      ENSP00000504875.1, ENST00000680646.1
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    3. NM_001394635.1NP_001381564.1  C-C motif chemokine 25 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS12194.1
      UniProtKB/Swiss-Prot
      A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
      UniProtKB/TrEMBL
      C9JDZ7
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    4. NM_001394636.1NP_001381565.1  C-C motif chemokine 25 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS12194.1
      UniProtKB/Swiss-Prot
      A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
      UniProtKB/TrEMBL
      C9JDZ7
      Related
      ENSP00000505422.1, ENST00000680506.1
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    5. NM_001394637.1NP_001381566.1  C-C motif chemokine 25 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS12194.1
      UniProtKB/Swiss-Prot
      A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
      UniProtKB/TrEMBL
      C9JDZ7
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    6. NM_001394638.1NP_001381567.1  C-C motif chemokine 25 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS56080.1
      UniProtKB/TrEMBL
      Q08AK2
      Related
      ENSP00000506202.1, ENST00000680450.1
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
    7. NM_005624.4NP_005615.2  C-C motif chemokine 25 isoform 1 precursor

      See identical proteins and their annotated locations for NP_005615.2

      Status: REVIEWED

      Source sequence(s)
      AC008946
      Consensus CDS
      CCDS12194.1
      UniProtKB/Swiss-Prot
      A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
      UniProtKB/TrEMBL
      C9JDZ7
      Related
      ENSP00000324756.6, ENST00000315626.6
      Conserved Domains (1) summary
      cd01119
      Location:2891
      Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      8052341..8062650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439203.1XP_047295159.1  C-C motif chemokine 25 isoform X1

    2. XM_047439204.1XP_047295160.1  C-C motif chemokine 25 isoform X2

      UniProtKB/Swiss-Prot
      A1L4J4, A6NI52, A8K9E7, B5MCA5, O15444, Q96KJ7
      UniProtKB/TrEMBL
      C9JDZ7
    3. XM_047439205.1XP_047295161.1  C-C motif chemokine 25 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      8053362..8063660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321712.1XP_054177687.1  C-C motif chemokine 25 isoform X1

    2. XM_054321713.1XP_054177688.1  C-C motif chemokine 25 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_148888.1: Suppressed sequence

      Description
      NM_148888.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.