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    CCL13 C-C motif chemokine ligand 13 [ Homo sapiens (human) ]

    Gene ID: 6357, updated on 10-Dec-2024

    Summary

    Official Symbol
    CCL13provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 13provided by HGNC
    Primary source
    HGNC:HGNC:10611
    See related
    Ensembl:ENSG00000181374 MIM:601391; AllianceGenome:HGNC:10611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13
    Summary
    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
    Expression
    Broad expression in colon (RPKM 14.2), small intestine (RPKM 11.9) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CCL13 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (34356480..34358610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (35303463..35305593)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (32683499..32685629)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:32624651-32625240 Neighboring gene C-C motif chemokine ligand 11 Neighboring gene C-C motif chemokine ligand 8 Neighboring gene C-C motif chemokine ligand 1 Neighboring gene uncharacterized LOC124903986 Neighboring gene NANOG hESC enhancer GRCh37_chr17:32736867-32737622

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC17134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 13
    Names
    CK-beta-10
    chemokine (C-C motif) ligand 13
    monocyte chemoattractant protein 4
    monocyte chemotactic protein 4
    new CC chemokine 1
    small inducible cytokine subfamily A (Cys-Cys), member 13
    small-inducible cytokine A13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005408.3NP_005399.1  C-C motif chemokine 13 precursor

      See identical proteins and their annotated locations for NP_005399.1

      Status: REVIEWED

      Source sequence(s)
      AC011193
      Consensus CDS
      CCDS11281.1
      UniProtKB/Swiss-Prot
      O95689, Q6ICQ6, Q99616
      Related
      ENSP00000225844.2, ENST00000225844.7
      Conserved Domains (1) summary
      smart00199
      Location:3189
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      34356480..34358610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      35303463..35305593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)