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    RSU1 Ras suppressor protein 1 [ Homo sapiens (human) ]

    Gene ID: 6251, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RSU1provided by HGNC
    Official Full Name
    Ras suppressor protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10464
    See related
    Ensembl:ENSG00000148484 MIM:179555; AllianceGenome:HGNC:10464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSP-1
    Summary
    This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (16590611..16817424, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (16609081..16835881, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (16632610..16859423, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 18, pseudogene Neighboring gene phosphotriesterase related Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:16561428-16561928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:16561929-16562429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3099 Neighboring gene complement C1q like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3100 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:16639108-16640307 Neighboring gene uncharacterized LOC124902385 Neighboring gene uncharacterized LOC124902384 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:16801281-16801433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:16829435-16829935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3106 Neighboring gene uncharacterized LOC105376435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3105 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:16864864-16865015 Neighboring gene MPRA-validated peak881 silencer Neighboring gene MPRA-validated peak882 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:16933270-16934469 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:16942960-16943677 Neighboring gene cubilin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:16970960-16971553 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17010389-17010952 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:17026880-17027039 Neighboring gene GATA motif-containing MPRA enhancer 283 Neighboring gene Sharpr-MPRA regulatory region 1431 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:17104252-17105451 Neighboring gene MPRA-validated peak883 silencer Neighboring gene MPRA-validated peak884 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:17157167-17158366

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells. Christou C, et al. Cell Signal, 2023 Jan. PMID 36375714
    2. Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma. Nikou S, et al. Clin Exp Med, 2023 Jul. PMID 35729367
    3. Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance. Geramoutsou C, et al. Pathol Res Pract, 2022 Jul. PMID 35642986
    4. Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform. Gkretsi V, et al. Sci Rep, 2019 Jul 11. PMID 31296919, Free PMC Article
    5. Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation. Louca M, et al. Sci Rep, 2019 May 23. PMID 31123330, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.
      Title: CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.
    2. Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.
      Title: Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma.
    3. Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.
      Title: Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.
    4. Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.
      Title: Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance.
    5. Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
      Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
    6. Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
      Title: Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
    7. RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling.
      Title: RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling.
    8. Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
      Title: Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
    9. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
      Title: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
    10. Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform.
      Title: Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    CUBN is a gene locus for albuminuria.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31034

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras suppressor protein 1
    Names
    rsu-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012425.4 → NP_036557.1  ras suppressor protein 1 isoform 1

      See identical proteins and their annotated locations for NP_036557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC073367, AK055596, BC005993, BG400752, BX647733
      Consensus CDS
      CCDS7112.1
      UniProtKB/Swiss-Prot
      A8KA46, D3DRU3, Q15404, Q6FI17
      UniProtKB/TrEMBL
      Q32Q10
      Related
      ENSP00000339521.5, ENST00000345264.10
      Conserved Domains (2) summary
      PLN00113
      Location:34 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_152724.3 → NP_689937.2  ras suppressor protein 1 isoform 2

      See identical proteins and their annotated locations for NP_689937.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been experimentally confirmed.
      Source sequence(s)
      AC073367, AK055596, BG400752, BX647733
      Consensus CDS
      CCDS31157.1
      UniProtKB/TrEMBL
      Q32Q10
      Related
      ENSP00000473588.1, ENST00000602389.1
      Conserved Domains (3) summary
      cd00116
      Location:27 → 140
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:12 → 34
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:34 → 93
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      16590611..16817424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425617.1 → XP_047281573.1  ras suppressor protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      16609081..16835881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366524.1 → XP_054222499.1  ras suppressor protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15404.3 GenPept UniProtKB/Swiss-Prot:Q15404

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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