Format

Send to:

Choose Destination
    • Showing Current items.

    RSU1 Ras suppressor protein 1 [ Homo sapiens (human) ]

    Gene ID: 6251, updated on 15-Jun-2019

    Summary

    Official Symbol
    RSU1provided by HGNC
    Official Full Name
    Ras suppressor protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10464
    See related
    Ensembl:ENSG00000148484 MIM:179555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSP-1
    Summary
    This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See RSU1 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (16590616..16817454, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (16632615..16859509, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phosphotriesterase related Neighboring gene uncharacterized LOC101928701 Neighboring gene complement C1q like 3 Neighboring gene Sharpr-MPRA regulatory region 4915 Neighboring gene uncharacterized LOC105376435 Neighboring gene cubilin Neighboring gene GATA motif-containing MPRA enhancer 283

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    CUBN is a gene locus for albuminuria.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31034

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras suppressor protein 1
    Names
    ras suppressor protein 1 variant 1
    ras suppressor protein 1 variant 2
    ras suppressor protein 1 variant 3
    ras suppressor protein 1 variant 5
    rsu-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012425.4NP_036557.1  ras suppressor protein 1 isoform 1

      See identical proteins and their annotated locations for NP_036557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC073367, AK055596, BC005993, BG400752, BX647733
      Consensus CDS
      CCDS7112.1
      UniProtKB/Swiss-Prot
      Q15404
      Related
      ENSP00000339521.5, ENST00000345264.10
      Conserved Domains (2) summary
      sd00033
      Location:1941
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:34200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. NM_152724.2NP_689937.2  ras suppressor protein 1 isoform 2

      See identical proteins and their annotated locations for NP_689937.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been experimentally confirmed.
      Source sequence(s)
      AK055596, BG400752, BX647733
      Consensus CDS
      CCDS31157.1
      UniProtKB/Swiss-Prot
      Q15404
      Related
      ENSP00000473588.1, ENST00000602389.1
      Conserved Domains (3) summary
      cd00116
      Location:27140
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:1234
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:3493
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      16590611..16817454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252552.4XP_005252609.1  ras suppressor protein 1 isoform X1

      Conserved Domains (4) summary
      cd00116
      Location:80193
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:4264
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:4180
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:87146
      LRR_8; Leucine rich repeat
    Support Center