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    RPS16 ribosomal protein S16 [ Homo sapiens (human) ]

    Gene ID: 6217, updated on 19-Jun-2019

    Summary

    Official Symbol
    RPS16provided by HGNC
    Official Full Name
    ribosomal protein S16provided by HGNC
    Primary source
    HGNC:HGNC:10396
    See related
    Ensembl:ENSG00000105193 MIM:603675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S16
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 933.9), lymph node (RPKM 484.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See RPS16 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39433137..39435949, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39923847..39926660, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon TAT) 1-1 Neighboring gene pleckstrin homology and RhoGEF domain containing G2 Neighboring gene SPT5 homolog, DSIF elongation factor subunit Neighboring gene small nucleolar RNA, C/D box 175 Neighboring gene translocase of inner mitochondrial membrane 50

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with RPL27AP6 as demonstrated by proximity dependent biotinylation proteomics PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
     
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
    Traceable Author Statement
    more info
     
    rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation IC
    Inferred by Curator
    more info
    PubMed 
    translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translational initiation TAS
    Traceable Author Statement
    more info
     
    viral transcription TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    40S ribosomal protein S16
    Names
    small ribosomal subunit protein uS9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020.6NP_001011.1  40S ribosomal protein S16 isoform 1

      See identical proteins and their annotated locations for NP_001011.1

      Status: REVIEWED

      Source sequence(s)
      AA890305, AC011500, AK315498
      Consensus CDS
      CCDS12535.1
      UniProtKB/Swiss-Prot
      P62249
      Related
      ENSP00000251453.2, ENST00000251453.8
      Conserved Domains (1) summary
      PLN00210
      Location:6146
      PLN00210; 40S ribosomal protein S16; Provisional
    2. NM_001321111.2NP_001308040.1  40S ribosomal protein S16 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AA890305, AC011500, BC095429
      Consensus CDS
      CCDS82349.1
      UniProtKB/TrEMBL
      M0R210
      Related
      ENSP00000472231.1, ENST00000601655.5
      Conserved Domains (1) summary
      PLN00210
      Location:6129
      PLN00210; 40S ribosomal protein S16; Provisional
    3. NM_001363860.2NP_001350789.1  40S ribosomal protein S16 isoform 3

      Status: REVIEWED

      Source sequence(s)
      BG340248, CB151553, CD249175
      Consensus CDS
      CCDS86768.1
      Conserved Domains (1) summary
      cl00334
      Location:686
      Ribosomal_S9; Ribosomal protein S9/S16

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      39433137..39435949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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