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    RPN1 ribophorin I [ Homo sapiens (human) ]

    Gene ID: 6184, updated on 7-Oct-2018

    Summary

    Official Symbol
    RPN1provided by HGNC
    Official Full Name
    ribophorin Iprovided by HGNC
    Primary source
    HGNC:HGNC:10381
    See related
    Ensembl:ENSG00000163902 MIM:180470; Vega:OTTHUMG00000159691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OST1; RBPH1
    Summary
    This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 116.8), placenta (RPKM 79.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See RPN1 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (128619970..128650876, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128338813..128369719, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 10 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 1565 Neighboring gene POU class 5 homeobox 1 pseudogene 6 Neighboring gene RAB7A, member RAS oncogene family Neighboring gene microtubule affinity regulating kinase 2 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic variation associated with circulating monocyte count in the eMERGE Network.
    NHGRI GWA Catalog
    Multiple loci are associated with white blood cell phenotypes.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of ribophorin I (RPN1) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686B16177

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein N-linked glycosylation via asparagine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein N-linked glycosylation via asparagine TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oligosaccharyltransferase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    rough endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
    Names
    RPN-I
    dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit
    oligosaccharyltransferase 1 homolog
    oligosaccharyltransferase complex subunit (non-catalytic)
    ribophorin-1
    NP_002941.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002950.3NP_002941.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

      See identical proteins and their annotated locations for NP_002941.1

      Status: REVIEWED

      Source sequence(s)
      AC079945, BC010839, BG720812
      Consensus CDS
      CCDS3051.1
      UniProtKB/Swiss-Prot
      P04843
      Related
      ENSP00000296255.3, OTTHUMP00000216245, ENST00000296255.7, OTTHUMT00000356934
      Conserved Domains (2) summary
      pfam04597
      Location:33457
      Ribophorin_I; Ribophorin I
      pfam10482
      Location:480596
      CtIP_N; tumor-suppressor protein CtIP N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      128619970..128650876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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